Alpha-Ketoglutarate (AKG): A Physician's Guide to the Longevity Molecule
Dr. Julian Douwes reviews the evidence on alpha-ketoglutarate (AKG) supplementation — from TCA cycle biochemistry to epigenetic aging and clinical dosing.
Longevity Medicine
Moderate EvidenceMitochondrial Health
Mitochondrial dysfunction, biogenesis, and strategies for cellular energy.
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Taurine and Longevity: A Physician's Evidence Review
Dr. Julian Douwes examines taurine's role in aging, the landmark 2023 Science study, clinical dosing protocols, and who stands to benefit most.
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Alpha-Lipoic Acid: Neuropathy, Heavy Metal Detox, and Mitochondrial Repair
Dr. Douwes reviews alpha-lipoic acid dosing, R-ALA vs racemic forms, clinical uses for neuropathy, heavy metal chelation support, and mitochondrial longevity.
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NAD Supplement Guide: NMN, NR, NADH and Oral NAD+ Precursors Compared
A physician's comparison of every oral NAD+ precursor — NMN, NR, NADH, and NAD3 — covering mechanisms, dosing, cofactors, and when to upgrade to IV therapy.
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IV Laser Therapy: A Physician's Complete Guide to Intravenous Photobiomodulation
A physician's guide to intravenous laser blood irradiation: mechanisms, clinical evidence, treatment protocols, and who benefits most from ILBI therapy.
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Urolithin A: Activating Mitophagy for Muscle Health and Longevity
Dr. Douwes reviews urolithin A — the gut-derived metabolite that activates mitophagy, preserves muscle function, and extends healthspan in clinical trials.
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Spermidine and Longevity: The Autophagy Activator Your Cells Are Waiting For
Spermidine triggers cellular autophagy, protects cardiovascular and cognitive health, and extends lifespan in animal models. What the human evidence actually shows.
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CoQ10 for Heart Health: What the Clinical Evidence Actually Shows
Cardiologist-reviewed guide to CoQ10 for heart failure, hypertension, and statin-related symptoms. Dosing, forms, and who benefits most.
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Photobiomodulation for Depression: What the Clinical Evidence Actually Shows
Dr. Douwes reviews transcranial photobiomodulation for depression — mechanisms, clinical trial data, dosing protocols, and how it fits an integrative mental health strategy.
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Ubiquinol vs Ubiquinone: Which Form of CoQ10 Actually Works Better?
Ubiquinol vs ubiquinone: understand the biochemical difference, absorption data, and when each form is clinically appropriate for your patients.
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NAD+ IV Side Effects: What to Expect and How to Manage Them
A physician's guide to NAD+ IV therapy side effects: what causes them, which are common vs serious, how to minimize discomfort, and who should avoid treatment.
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CoQ10 for Statin Users: Why Your Cholesterol Medication Depletes CoQ10
Physician guide to CoQ10 depletion from statins. Why it happens, symptoms of statin-induced CoQ10 deficiency, optimal dosing with ubiquinol, and what the evidence shows.
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Organic Acids Test (OAT): What It Reveals
Complete guide to the Organic Acids Test. What the 70+ markers mean, what OAT reveals about mitochondrial function, neurotransmitters, and gut health, and when to order it.
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Photobiomodulation for Brain Fog: Mitochondrial Rescue
How photobiomodulation targets mitochondrial dysfunction to clear brain fog. Mechanism, clinical evidence, and practical application for chronic illness patients.
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Zone 2 Training: The Foundation of Cardiovascular Longevity
Why Zone 2 cardio is the single most important exercise modality for longevity. Mitochondrial biogenesis, fat oxidation, VO2 max, and practical programming.
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Chronic Fatigue Syndrome: A Physician's Complete Guide
A physician's complete guide to chronic fatigue syndrome. Mitochondrial dysfunction, immune dysregulation, diagnostic criteria, and the stepwise treatment approach we use at Klinik St. Georg.
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Mitochondrial Medicine: The Energy Crisis
Why mitochondrial dysfunction underlies fatigue, cognitive decline, and aging. Testing, treatment, and what actually improves mitochondrial function.
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CoQ10: Ubiquinol vs Ubiquinone — What Actually Matters
Evidence-based guide to CoQ10 supplementation. Ubiquinol vs ubiquinone, absorption differences, statin interactions, mitochondrial function, and what I recommend in clinical practice.
