Longevity Medicine
Moderate EvidenceMitochondrial dysfunction, biogenesis, and strategies for cellular energy.
Dr. Douwes reviews the 24-month LIGHTSITE III trial data on PBM for dry AMD, mechanism, patient selection, dosing protocols, and where this therapy fits in practice.
How red and near-infrared light therapy modulates circadian rhythm, melatonin, and slow-wave sleep — with dosing protocol and patient selection criteria.
Evidence-based MOTS-c dosage guide covering subcutaneous injection protocols, cycling schedules, stacking strategies, and who benefits most from this mitochondrial peptide.
A physician's guide to NAD+ IV therapy contraindications — cancer history, active infections, G6PD deficiency, cardiac conditions, and pregnancy.
Evidence-based methylene blue dosage guide covering cognitive, mitochondrial, and antimicrobial applications with safety protocols and contraindications.
Physician-reviewed urolithin A dosage guide: optimal dose from 500mg to 2g, timing, cycling, and stacking protocols backed by clinical evidence.
CoQ10 supplementation may improve egg quality, embryo viability, and sperm parameters. A physician's evidence review covering dosage, form, and who benefits most.
D-ribose is a five-carbon sugar that drives ATP synthesis. Learn how it helps chronic fatigue, fibromyalgia, Lyme fatigue, and post-COVID exhaustion.
L-ergothioneine is a unique cytoprotective amino acid found in mushrooms and aged cheeses. Learn how it protects mitochondria, slows aging, and why your cells hold onto it so tightly.
Plasmalogen deficiency accelerates cognitive decline. Learn what these critical ether phospholipids do, why they drop with age, and the clinical evidence for supplementation.
How mitochondrial dysfunction drives fatigue, brain fog, and chronic illness — plus clinical testing and protocols to restore cellular energy production.
A physician's review of molecular hydrogen water — mechanisms, clinical trial data, dosing, and how it fits a longevity protocol. Evidence-based, hype-free.
Mitophagy removes damaged mitochondria to protect energy, cognition, and lifespan. A physician explains what activates it, what blocks it, and how to optimize it.
Pyrroloquinoline quinone (PQQ) promotes mitochondrial biogenesis, neuroprotection, and cellular energy. Dr. Douwes reviews the evidence and clinical dosing protocols.
A physician's guide to astaxanthin—6,000× more potent than vitamin C—with clinical evidence for heart health, neuroprotection, eye health, and longevity.
A physician's guide to sirtuins—the NAD+-dependent enzymes that regulate aging, metabolism, DNA repair, and inflammation across every organ system.
Hormesis is the biological phenomenon where low-dose stressors trigger adaptive responses that strengthen resilience, slow aging, and extend healthspan. A physician's guide.
A physician's review of the four most-studied medicinal mushrooms — what the clinical evidence actually shows and how I use them in integrative practice.
Clinical review of NMN supplementation: mechanisms, human trial data, optimal dosing (250–1,000 mg/day), forms ranked by bioavailability, and candidacy criteria.
Acetyl-L-Carnitine (ALCAR) supports mitochondrial energy, acetylcholine synthesis, and nerve repair. Dr. Douwes reviews the clinical evidence, dosing, and stacking strategies.
GlyNAC supplementation restores glutathione, reverses mitochondrial dysfunction, and improves multiple hallmarks of aging. Clinical evidence and physician dosing guide.
Dr. Julian Douwes reviews humanin, the mitochondria-derived peptide with neuroprotective, insulin-sensitizing, and anti-aging effects backed by clinical research.
Creatine does far more than build muscle. This physician-reviewed guide covers creatine supplementation for longevity, cognitive health, and sarcopenia prevention.
MOTS-c is a mitochondria-encoded peptide that activates AMPK, improves insulin sensitivity, and may extend healthspan. A physician's clinical overview.
A physician's clinical guide to shilajit — how fulvic acid drives mitochondrial energy, supports testosterone, and offers neuroprotective effects. Dosing, forms, and safety.
Sulforaphane activates the NRF2 pathway to upregulate cellular defenses. A physician's review of clinical evidence, bioavailability, and dosing strategies.
A physician's evidence-based guide to TUDCA — how this bile acid supports liver health, stabilizes mitochondria, reduces ER stress, and protects neurons.
Dr. Julian Douwes reviews the evidence on alpha-ketoglutarate (AKG) supplementation — from TCA cycle biochemistry to epigenetic aging and clinical dosing.
Dr. Julian Douwes examines taurine's role in aging, the landmark 2023 Science study, clinical dosing protocols, and who stands to benefit most.
Dr. Douwes reviews alpha-lipoic acid dosing, R-ALA vs racemic forms, clinical uses for neuropathy, heavy metal chelation support, and mitochondrial longevity.
A physician's comparison of every oral NAD+ precursor — NMN, NR, NADH, and NAD3 — covering mechanisms, dosing, cofactors, and when to upgrade to IV therapy.
A physician's guide to intravenous laser blood irradiation: mechanisms, clinical evidence, treatment protocols, and who benefits most from ILBI therapy.
Dr. Douwes reviews urolithin A — the gut-derived metabolite that activates mitophagy, preserves muscle function, and extends healthspan in clinical trials.
Spermidine triggers cellular autophagy, protects cardiovascular and cognitive health, and extends lifespan in animal models. What the human evidence actually shows.
Cardiologist-reviewed guide to CoQ10 for heart failure, hypertension, and statin-related symptoms. Dosing, forms, and who benefits most.
Dr. Douwes reviews transcranial photobiomodulation for depression — mechanisms, clinical trial data, dosing protocols, and how it fits an integrative mental health strategy.
Ubiquinol vs ubiquinone: understand the biochemical difference, absorption data, and when each form is clinically appropriate for your patients.
A physician's guide to NAD+ IV therapy side effects: what causes them, which are common vs serious, how to minimize discomfort, and who should avoid treatment.
Physician guide to CoQ10 depletion from statins. Why it happens, symptoms of statin-induced CoQ10 deficiency, optimal dosing with ubiquinol, and what the evidence shows.
Complete guide to the Organic Acids Test. What the 70+ markers mean, what OAT reveals about mitochondrial function, neurotransmitters, and gut health, and when to order it.
How photobiomodulation targets mitochondrial dysfunction to clear brain fog. Mechanism, clinical evidence, and practical application for chronic illness patients.
Why Zone 2 cardio is the single most important exercise modality for longevity. Mitochondrial biogenesis, fat oxidation, VO2 max, and practical programming.
A physician's complete guide to chronic fatigue syndrome. Mitochondrial dysfunction, immune dysregulation, diagnostic criteria, and the stepwise treatment approach we use at Klinik St. Georg.
Why mitochondrial dysfunction underlies fatigue, cognitive decline, and aging. Testing, treatment, and what actually improves mitochondrial function.
Evidence-based guide to CoQ10 supplementation. Ubiquinol vs ubiquinone, absorption differences, statin interactions, mitochondrial function, and what I recommend in clinical practice.
