Foundational
What I Changed My Mind About: Long-Term Antibiotics for Chronic Lyme
A physician's honest account of evolving clinical perspective on long-term antibiotic therapy for chronic Lyme disease, and what changed.
Infectiology
Moderate EvidenceLyme Disease (Borrelia)
Chronic Borrelia infection — diagnosis, treatment, and the persistent disease controversy.
01
02
IDSA vs ILADS: The Lyme Disease Guideline War and What It Means for Patients
Why the IDSA and ILADS Lyme disease guidelines have been in conflict for decades, what each says, and how the evidence debate affects real patients.
03
Combination Antibiotics for Lyme Disease: What the Tulane and Northwestern Research Means for PTLDS Patients
New animal research finds combination antibiotic regimens outperform monotherapy for persistent Lyme infection — and piperacillin shows microbiome-sparing promise.
04
Treatment-Resistant Depression: The Cause-First Workup Before TMS
Before treating TRD, investigate the cause: qEEG brain mapping, CRP inflammation testing, Lyme/viral infections, and toxic relationships. Julian's clinical protocol.
05
Photobiomodulation for Peripheral Neuropathy: Clinical Evidence and Protocol Guide
How red and near-infrared light therapy reduces nerve pain, improves sensation, and supports nerve repair in diabetic, Lyme-related, and chemotherapy-induced neuropathy.
06
Andrographis Paniculata: Evidence, Dosing, and Clinical Use in Lyme Disease and Immune Support
A clinician's guide to andrographis paniculata—active mechanisms, RCT evidence for respiratory infections, Lyme disease adjunct protocols, dosing, and safety considerations.
07
Ultraviolet Blood Irradiation (UVBI): A Physician's Clinical Protocol Guide
Dr. med. univ. Julian Douwes explains UVBI therapy — mechanisms, clinical indications, treatment protocol, contraindications, and how it compares to IV laser and ozone.
08
Dapsone, Disulfiram, and Azlocillin in Lyme Disease: Combination Protocols for Persister Cells
An evidence-based review of emerging repurposed-drug protocols—dapsone, disulfiram, and azlocillin—targeting Borrelia persister cells in chronic Lyme disease.
09
5-HTP and Tryptophan: A Physician's Guide to Serotonin Precursors for Sleep, Mood, and Brain Fog
Dr. med. univ. Julian Douwes explains 5-HTP vs tryptophan for serotonin support — dosing, safety, interactions, and clinical use in Lyme disease and post-COVID patients.
10
Benfotiamine for Peripheral Neuropathy: A Physician's Evidence Review
Fat-soluble thiamine that crosses cell membranes conventional B1 cannot. How benfotiamine repairs peripheral nerves, reduces oxidative stress, and supports recovery in Lyme, diabetes, and post-COVID neuropathy.
11
Lumbrokinase vs Nattokinase: Which Fibrinolytic Enzyme Is Right for You?
Comparing lumbrokinase and nattokinase for fibrin clearance, biofilm disruption, post-COVID microclots, and cardiovascular health — with clinical dosing guidance.
12
D-Ribose for Chronic Fatigue: Restoring Cellular Energy from the Ground Up
D-ribose is a five-carbon sugar that drives ATP synthesis. Learn how it helps chronic fatigue, fibromyalgia, Lyme fatigue, and post-COVID exhaustion.
13
Mitochondrial Dysfunction: Root Causes, Testing, and Evidence-Based Treatment
How mitochondrial dysfunction drives fatigue, brain fog, and chronic illness — plus clinical testing and protocols to restore cellular energy production.
14
Serrapeptase vs Nattokinase: Which Fibrinolytic Enzyme Is Right for You?
A physician-led comparison of serrapeptase and nattokinase: mechanisms, clinical evidence, dosing, and which fibrinolytic enzyme fits your health goals.
15
Selenium: Thyroid Protection, Antioxidant Defense & Heavy Metal Detox
A physician's guide to selenium dosing, forms, and clinical uses for thyroid health, glutathione recycling, mercury detox, and immune support.
16
Lumbrokinase: The Fibrinolytic Enzyme Your Doctor Probably Hasn't Mentioned
Lumbrokinase is a potent fibrinolytic enzyme with emerging evidence for post-COVID microclots, Lyme biofilms, and chronic inflammation. A physician's clinical overview.
17
L-Glutamine for Gut Health: Leaky Gut, Mucosal Repair, and Clinical Dosing
L-glutamine is the intestinal lining's primary fuel source. Explore the clinical evidence for leaky gut, Lyme dysbiosis, post-COVID recovery, and optimal dosing protocols.
18
Tick-Borne Encephalitis: Diagnosis, Prevention, and Integrative Treatment
A physician's guide to tick-borne encephalitis—epidemiology, diagnosis, clinical staging, vaccination, and integrative recovery protocols for European patients.
19
Ozone Therapy for Lyme Disease: Clinical Evidence, Protocols & What to Expect
How ozone therapy works against Borrelia and co-infections, which protocols are used clinically, and what published evidence says about its role in Lyme care.
20
Hyperbaric Oxygen Therapy for Longevity and Recovery: A Physician's Review
Dr. Douwes reviews hyperbaric oxygen therapy (HBOT): how it works, what the clinical evidence says for longevity, post-COVID, Lyme, and neurological recovery.
21
Low-Dose Naltrexone (LDN): Clinical Evidence for Chronic Illness and Autoimmunity
Low-dose naltrexone modulates immune function and reduces neuroinflammation. Evidence-based overview of LDN dosing, mechanisms, and clinical applications.
22
Whole-Body Hyperthermia for Lyme Disease: Evidence, Mechanism, and Clinical Protocols
Comprehensive guide to whole-body hyperthermia for chronic Lyme disease. Mechanism of action, evidence base, clinical protocols, and patient outcomes from a physician who performs it.
23
Lyme Disease Treatment in Germany: Why Patients Travel for Care
Why patients travel to Germany for Lyme disease treatment. German clinic advantages, treatment approaches, costs, logistics, and what to expect at St. George Hospital.
24
Stem Cell Therapy for Lyme Disease: An Honest Evidence Review
Honest physician's assessment of stem cell therapy for Lyme disease. Current evidence level, what patients should know, legitimate applications vs red flags in stem cell tourism.
25
What to Expect: Whole-Body Hyperthermia Treatment Day by Day
A day-by-day walkthrough of whole-body hyperthermia at St. George Hospital. From consultation to recovery, what happens at every stage of your treatment journey.
26
Whole-Body Hyperthermia vs IV Antibiotics for Lyme Disease
A physician's comparison of whole-body hyperthermia and IV antibiotics for Lyme disease — mechanisms, evidence, recurrence rates, and when each approach is appropriate.
27
Western Blot vs ELISA: Lyme Testing Accuracy Compared
Head-to-head comparison of Western Blot and ELISA for Lyme disease. Sensitivity at each stage, what the bands mean, the two-tier protocol, and why the system misses patients.
28
Neurofeedback for Lyme Brain Fog
How neurofeedback retrains dysregulated brainwave patterns in Lyme disease patients. qEEG findings, clinical evidence, and what to expect from treatment.
29
PEMF for Lyme Disease and Chronic Pain
How pulsed electromagnetic field therapy supports pain relief and inflammation reduction in Lyme disease — mechanism, clinical evidence, and practical considerations.
30
Lyme Treatment: Germany vs the United States
A direct comparison of American IDSA Lyme guidelines and German integrative Lyme treatment. Why patients travel to Germany, what's different, and what the evidence supports.
31
Managing Herxheimer Reactions at Home
Evidence-based strategies for managing Jarisch-Herxheimer reactions during Lyme treatment — hydration, detox support, dose pacing, and when to call your doctor.
32
Is Herxing a Good Sign? What Die-Off Actually Means
Does a Herxheimer reaction mean treatment is working? The science behind die-off, why worse does not always mean better, and the goal of controlled pathogen clearance.
33
How Reactivated Viruses Suppress Your Immune System
The immune suppression cascade: how Lyme disease triggers EBV, HHV-6, and CMV reactivation, and how these viruses further suppress immunity in a vicious cycle.
34
CD57 Test in Lyme Disease: Useful or Unreliable?
The CD57 test in Lyme disease — what it measures, Dr. Stricker's original hypothesis, conflicting study results, and how clinicians actually use it in practice.
35
iSpot Lyme T-Cell Test: A Better Way to Detect Borrelia?
How the iSpot Lyme (ELISpot) T-cell test works, its advantages over antibody testing, 84% sensitivity data, limitations, and when it adds clinical value.
36
Why Antibiotics Alone Fail Against Biofilms
How bacterial biofilms reduce antibiotic efficacy by 100-1,000x, why standard treatment courses miss persistent infections, and what integrative approaches add.
37
Brain Fog and Neuroinflammation: The PET Scan Evidence
What causes brain fog in Lyme disease — Johns Hopkins PET scan findings showing glial activation, neuroinflammation mechanisms, and treatment implications.
38
HHV-6 and Lyme Disease: The Co-Reactivation Problem
Why HHV-6 reactivates in virtually all chronic Lyme patients, its contribution to neurological symptoms, and testing and treatment approaches.
39
Clearing Brain Fog After Treatment: Recovery Timeline
What to expect during brain fog recovery after Lyme treatment — the multi-system recovery approach, realistic timelines, and evidence-based strategies.
40
Lyme Disease, Gut Dysbiosis, and Leaky Gut
How Lyme disease disrupts the gut microbiome. Antibiotic-driven dysbiosis, Borrelia's effect on intestinal permeability, the Hopkins microbiome findings, and recovery strategies.
41
Hyperthermia Side Effects and What to Expect During Treatment
Honest guide to whole-body hyperthermia side effects. What happens during treatment, common reactions, Herxheimer responses, recovery timeline, and contraindications.
42
Herxheimer Reaction vs Disease Flare: How to Tell the Difference
A clinical framework for distinguishing Jarisch-Herxheimer reactions from disease flares in Lyme treatment — timing, symptom patterns, and when to act.
43
Biofilm Disruption Protocols for Chronic Infections
A clinical overview of biofilm disruption strategies for persistent Lyme disease — the three-phase approach of disrupt, kill, and clear.
44
LL-37 for Biofilm Disruption in Chronic Lyme
How LL-37 disrupts Borrelia biofilms in chronic Lyme disease. Mechanism, preclinical evidence, protocol context, safety, and the evidence gaps.
45
Lyme Disease False Negatives: Why Standard Tests Miss Chronic Lyme
Why Lyme disease tests come back negative in patients with active infection. ELISA sensitivity gaps, antibody window, seronegative Lyme, and what to do when tests miss.
46
Brain Fog Treatment: A Physician's Complete Guide
Brain fog treatment options from neuroinflammation workup to neuromodulation. Causes include post-COVID, Lyme, MCAS, and mold. TPS, NAD+, and hyperbaric oxygen covered.
47
Lyme Testing: Why Standard ELISA Fails
Why standard Lyme disease tests miss infections, and which advanced tests provide accurate results. ELISpot, CD57, and beyond.
48
Whole-Body Hyperthermia for Lyme: Why 2 Sessions, Not 6
Why St. George Hospital uses 2 extreme hyperthermia sessions at 41.6-41.8°C for chronic Lyme, not 5-6 moderate sessions. The rationale, and what the evidence does and does not show.
49
Antibiotic Resistance and Alternatives
How antibiotic resistance affects chronic infection treatment and what alternatives exist. A physician's perspective on navigating a post-antibiotic landscape.
50
Chronic Lyme Disease: What Medicine Misses
What conventional medicine gets wrong about chronic Lyme disease, why standard treatment fails some patients, and our integrative approach.
51
Medical Treatment in Germany: A Complete Guide for International Patients
Everything international patients need to know about medical treatment in Germany. Visa, costs, insurance, travel logistics, and what to expect at St. George Hospital in Bad Aibling — based on treating patients from 90+ countries.
52
Neuroborreliosis: When Lyme Crosses the Blood-Brain Barrier
How Borrelia invades the central nervous system, why neuroborreliosis is underdiagnosed, and how hyperthermia, TPS, and multimodal protocols treat what antibiotics alone cannot reach.
53
Lyme Support Protocol: Between Treatments
A supplement and lifestyle protocol for Lyme disease patients between clinical treatments. Evidence levels included. By Dr. med. univ. Julian Douwes.
54
Why Patients Fly to Germany for Lyme Treatment
Why international patients seek Lyme disease treatment in Germany. Medical culture, treatment options, and what makes the German approach different.
55
Lyme Disease Symptoms: The Complete Checklist Doctors Miss
Lyme disease symptom checklist covering neurological, musculoskeletal, cardiac, psychiatric, and GI manifestations, drawing on St. George Hospital's experience with 12,000+ Lyme patients.
56
What Is Whole-Body Hyperthermia? A Complete Guide
Whole body hyperthermia treatment explained by a physician. How controlled fever therapy works for Lyme, cancer, and post-COVID at St. George Hospital.
57
Peptide Therapy for Lyme Disease: Protocol, Doses and Evidence
Thymosin alpha-1, LL-37 and BPC-157 in chronic Lyme: the phased protocol and doses used alongside antibiotics, the evidence for each, and the risks.
