Clinical Immunology
Strong EvidenceChronic low-grade inflammation, cytokine storms, and resolution pathways.
Vagus nerve stimulation benefits explained by a physician. Invasive vs non-invasive VNS, cold exposure, HRV measurement, and clinical evidence for inflammation and depression.
How LDN modulates neuroinflammation and opioid signalling to reduce PTSD symptom burden — evidence review and physician-guided dosing protocol. (158 chars)
Can LDN slow Parkinson's progression? Dr. Douwes reviews the microglial mechanism, emerging clinical data, dosing protocol, and who is a suitable candidate.
LDN reduces endometriosis pain by modulating neuroinflammation and opioid growth factor signaling. Dr. Douwes reviews dosing protocols and the emerging evidence base.
Semaglutide and tirzepatide do more than control weight. Here's what the clinical evidence shows about GLP-1 agonists for cognitive protection and Alzheimer's risk reduction.
How LDN modulates opioid growth factor receptors and neuroinflammation to reduce psoriatic arthritis joint pain and skin flares — dosing, evidence, and who benefits most.
LDN modulates mu-opioid receptors and TLR4 signalling to reduce itch and inflammation in atopic dermatitis. Learn dosing, monitoring, and who benefits most.
A clinical guide to low-dose naltrexone (LDN) in multiple sclerosis: mechanisms, clinical trial data, dosing protocols, patient selection, and integration with DMTs.
How LDN modulates gut immunity, reduces inflammation, and offers a low-risk adjunct in IBD — dosing, evidence hierarchy, patient selection, and monitoring.
LDN reduces fibromyalgia pain by modulating microglial neuroinflammation. Review clinical trial data, optimal dosing protocols, and what to expect in the first 90 days.
How vitamin D acts as a lifespan neuroimmune signal in psychiatry — from depression and schizophrenia to autism and cognitive decline. Clinical dosing and evidence.
VNS in rheumatoid arthritis — RESET-RA trial results, patient selection criteria, integration with DMARDs, and how bioelectronic medicine is reshaping RA treatment.
LDN reduces neuroinflammation and immune dysregulation driving long COVID fatigue. Clinical evidence, dosing protocol, and how LDN fits a multimodal recovery plan.
A physician's guide to the D+Q senolytic combination — clinical evidence, dosing schedule, cycling intervals, patient selection, and lab monitoring for longevity practice.
A physician's roadmap to treating Chronic Inflammatory Response Syndrome—from CSM binding to VIP nasal spray—with integrative additions for refractory cases.
Inflammaging drives biological aging, cardiovascular disease, and neurodegeneration. Learn the science, key biomarkers, and evidence-based interventions from an integrative physician.
Plasmalogen deficiency accelerates cognitive decline. Learn what these critical ether phospholipids do, why they drop with age, and the clinical evidence for supplementation.
A physician's guide to HBOT for Long COVID — covering the mechanisms, clinical trial data, patient selection, session protocols, and realistic outcome expectations.
A physician's review of molecular hydrogen water — mechanisms, clinical trial data, dosing, and how it fits a longevity protocol. Evidence-based, hype-free.
Discover how immunomodulatory peptides like Thymosin Alpha-1, BPC-157, and LL-37 can help regulate immune dysfunction in autoimmune conditions. Clinical protocols and evidence.
A physician-led comparison of serrapeptase and nattokinase: mechanisms, clinical evidence, dosing, and which fibrinolytic enzyme fits your health goals.
Lumbrokinase is a potent fibrinolytic enzyme with emerging evidence for post-COVID microclots, Lyme biofilms, and chronic inflammation. A physician's clinical overview.
Akkermansia muciniphila strengthens gut barrier integrity, improves metabolic markers, and predicts immunotherapy response. A clinical review of supplementation evidence.
A physician's guide to tick-borne encephalitis—epidemiology, diagnosis, clinical staging, vaccination, and integrative recovery protocols for European patients.
Dr. Julian Douwes reviews why boron belongs in a serious longevity stack — from free testosterone elevation and bone protection to vitamin D activation and CRP reduction.
Dr. Julian Douwes reviews PEA (palmitoylethanolamide) for chronic inflammation, neuropathic pain, and immune modulation — dosing, evidence, and clinical use.
Semax is a synthetic ACTH-derived peptide that upregulates BDNF, enhances focus and memory, and offers neuroprotection — used clinically in Russia for decades.
Physician's guide to PEMF frequency selection—from 1 Hz sleep protocols to 100 Hz inflammation reduction. Know which settings match your condition.
Dr. Douwes reviews hyperbaric oxygen therapy (HBOT): how it works, what the clinical evidence says for longevity, post-COVID, Lyme, and neurological recovery.
Low-dose naltrexone modulates immune function and reduces neuroinflammation. Evidence-based overview of LDN dosing, mechanisms, and clinical applications.
A physician's evidence-based breakdown of cold plunge physiology — from norepinephrine spikes to metabolic shifts, and how to dose cold water immersion safely.
Dr. Douwes reviews transcranial photobiomodulation for depression — mechanisms, clinical trial data, dosing protocols, and how it fits an integrative mental health strategy.
How pulsed electromagnetic field therapy supports pain relief and inflammation reduction in Lyme disease — mechanism, clinical evidence, and practical considerations.
How the KPV tripeptide reduces gut inflammation. NF-kB inhibition, PepT1 uptake, IBD and colitis evidence, oral dosing, and clinical observations.
What causes brain fog in Lyme disease — Johns Hopkins PET scan findings showing glial activation, neuroinflammation mechanisms, and treatment implications.
Evidence-based omega-3 dosing for inflammation. How much EPA and DHA for joint pain, cardiovascular inflammation, neuroinflammation, and autoimmune conditions. Physician protocols.
A physician's evidence-based protocol for reducing chronic inflammation through diet, lifestyle, and targeted supplementation.
How the vagus nerve controls inflammation through the cholinergic anti-inflammatory pathway. Mechanism, clinical significance, and implications for chronic illness.
How chronic low-grade inflammation drives disease, what causes it, and evidence-based strategies to address it. By Dr. Julian Douwes.
Why histamine intolerance is a systemic condition, not just allergies. Mechanisms, diagnostic pitfalls, gut-immune connections, and treatment strategies from clinical experience.
A physician's guide to MCAS — mechanism, symptoms, diagnostic criteria, treatment, and the connection to Lyme, mold, and EBV. Based on clinical experience treating patients with complex multi-system illness.
The bioavailability problem with curcumin explained. Comparing Meriva, Longvida, BCM-95, Theracurmin, liposomal, and piperine forms. Dosing by condition.
What causes a cytokine storm, how it damages the body, and what physicians can do about it. A clinical explanation by Dr. Julian Douwes.
The bidirectional gut-brain axis governs mood, cognition, and immune balance. Dr. Julian Douwes explains the science and integrative protocols for restoring this critical communication pathway.
