Clinical Protocols
Emerging EvidenceCognitive enhancement through nootropics, neurofeedback, and lifestyle interventions.
Bacopa monnieri improves memory, reduces anxiety, and protects neurons. Discover the clinical evidence, optimal dosing, forms, and who benefits most from this Ayurvedic nootropic.
Clinical evidence shows creatine monohydrate boosts cognitive performance under sleep deprivation, in vegetarians, and after TBI—far beyond its muscle reputation.
Grip strength is one of the most powerful predictors of all-cause mortality, cardiovascular disease, and cognitive decline. Here is what the evidence shows and what to do about it.
Precise Semax dosing by variant — 0.1% standard, NA-Semax, NA-Semax Amidate — with cycling schedules, titration steps, and nasal administration technique.
A clinical review of CDP-choline (citicoline) for cognitive function, brain fog, and neuroprotection — with dosing protocols, mechanisms, and comparison to alpha-GPC.
Evidence-based methylene blue dosage guide covering cognitive, mitochondrial, and antimicrobial applications with safety protocols and contraindications.
Compare the top nootropic peptides—Semax, Selank, Dihexa, Humanin, and DSIP—with clinical evidence, dosing protocols, and candidacy criteria from an integrative physician.
Plasmalogen deficiency accelerates cognitive decline. Learn what these critical ether phospholipids do, why they drop with age, and the clinical evidence for supplementation.
Klotho protein declines with age and predicts cognitive decline, kidney disease, and cardiovascular risk. Here's what the science says about boosting it.
Pregnenolone is the master precursor to all steroid hormones. Learn how declining levels affect cognition, stress response, and how to supplement safely under clinical guidance.
Clinical review of L-theanine: mechanisms, optimal dosing for anxiety, sleep, and cognitive performance, plus evidence-based stacking protocols for adult patients.
Dr. Douwes explains how phosphatidylcholine supports liver detoxification, cognitive function, and cellular membrane integrity — and who needs it most.
Dr. Julian Douwes reviews Alpha-GPC dosing, mechanisms, clinical evidence for brain performance, acetylcholine synthesis, and how it compares to other choline sources.
Acetyl-L-Carnitine (ALCAR) supports mitochondrial energy, acetylcholine synthesis, and nerve repair. Dr. Douwes reviews the clinical evidence, dosing, and stacking strategies.
A physician's guide to lithium orotate microdosing — mechanisms of neuroprotection, evidence for mood stability, Alzheimer's prevention research, and safe dosing protocols.
Creatine does far more than build muscle. This physician-reviewed guide covers creatine supplementation for longevity, cognitive health, and sarcopenia prevention.
A physician's clinical guide to shilajit — how fulvic acid drives mitochondrial energy, supports testosterone, and offers neuroprotective effects. Dosing, forms, and safety.
A physician's clinical guide to phosphatidylserine — how it supports memory, blunts cortisol, and slows cognitive aging. Evidence-based dosage and protocols.
A physician's guide to Rhodiola rosea — how it modulates the HPA axis, reduces stress-related fatigue, and improves cognitive performance in clinical practice.
Semax is a synthetic ACTH-derived peptide that upregulates BDNF, enhances focus and memory, and offers neuroprotection — used clinically in Russia for decades.
What to expect during brain fog recovery after Lyme treatment — the multi-system recovery approach, realistic timelines, and evidence-based strategies.
When to get neuropsychological testing for brain fog. What the evaluation measures, how it differs from standard neurology exams, and what the results mean for treatment.
Dihexa dosing guide by Dr. Julian Douwes. Oral and subcutaneous protocols, the c-Met safety question, and why caution is warranted with this potent nootropic peptide.
Brain fog treatment options from neuroinflammation workup to neuromodulation. Causes include post-COVID, Lyme, MCAS, and mold. TPS, NAD+, and hyperbaric oxygen covered.
Evidence-based protocol for mental clarity, focus, and memory from a physician who treats cognitive dysfunction daily.
