Creatine Dosage Guide: Loading, Maintenance, and Timing Protocols
Evidence-based creatine dosage protocols — loading vs skip-load, daily maintenance, timing windows, and form selection for performance and longevity.
Clinical Protocols
Emerging EvidenceBrain Performance Protocol
Cognitive enhancement through nootropics, neurofeedback, and lifestyle interventions.
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Adamax: The Semax Analog With No Published Studies
Adamax is a designer Semax analog with an adamantane cap borrowed from P021. No study has tested it; what is known, what users report, and the dosing in circulation.
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Cerebrolysin: What the Stroke and Dementia Trials Actually Show
Cerebrolysin is a pig-brain peptide drug licensed in Austria and other countries. Cochrane reviews, the CASTA and CARS trials, label doses and community use.
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Cortagen (AEDP): Brain Bioregulator and Nerve-Repair Data
Cortagen (Ala-Glu-Asp-Pro) is a Khavinson brain-cortex tetrapeptide. Rat nerve-regeneration and ischaemia data exist; human evidence is an unpublished claim.
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Intranasal Oxytocin: A Famous Effect That Keeps Failing Replication
Intranasal oxytocin has hundreds of trials and a replication problem. What the large RCTs and registered replications show, how it is dosed, and what users report.
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P021 (P21): The CNTF-Derived Peptide With Only Mouse Data
P021 is a CNTF-derived peptide that boosted neurogenesis and memory in mice and rats. No human study exists. Mechanism, evidence, community dosing and risks.
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PE-22-28 (Mini-Spadin): A TREK-1 Peptide Tested Only in Mice
PE-22-28 is a 7-amino-acid spadin analog that blocks the TREK-1 channel and acted as a fast antidepressant in mice. No human has received it in a study.
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Pinealon (EDR): Brain Bioregulator, Evidence and Dosing
Pinealon (Glu-Asp-Arg) is a Khavinson tripeptide sold for the brain. Cell and mouse data plus one small uncontrolled human study. Evidence, dosing and reports.
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Vesugen (KED): Vascular Bioregulator, Evidence and Dosing
Vesugen (Lys-Glu-Asp) is a Khavinson Cytogen sold for blood vessels. Endothelial cell data, Alzheimer mouse work and one small human study. What it shows.
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Brain Aging and Cognitive Reserve: What Is Established, What Is Emerging
What protects the aging brain? Risk factors and lifestyle trials vs zoster-vaccine signals and neuromodulation, each graded by strength of evidence.
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Tesamorelin and the Aging Brain: One Trial, Many Questions
A 2012 RCT linked the GHRH analogue tesamorelin to better executive function in older adults. Why one trial is not enough, plus safety and legal status.
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Lion's Mane Dosage: Physician Protocol for Cognitive and Nerve Benefits
Evidence-based lion's mane dosage guide covering optimal doses for cognition, neuropathy, and gut health—plus timing, cycling, forms, and who should avoid it.
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Methylene Blue as a Nootropic: Mitochondrial Mechanisms, Dosing Protocol, and Safety
Methylene blue enhances mitochondrial electron transport, improves memory, and reduces brain fog. Learn dosing protocols, evidence, and key safety limits.
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GLP-1 Agonists and Alzheimer's Prevention: What the Evidence Shows in 2026
Semaglutide and tirzepatide do more than control weight. Here's what the clinical evidence shows about GLP-1 agonists for cognitive protection and Alzheimer's risk reduction.
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Creatine for Women: Dosage, Hormonal Effects & Clinical Evidence
A physician's guide to creatine supplementation for women — hormone interactions, optimal dosage by cycle phase, menopause benefits, and what the evidence actually shows.
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Bacopa Monnieri: A Physician's Evidence-Based Guide to Cognitive Enhancement and Stress Resilience
Bacopa monnieri improves memory, reduces anxiety, and protects neurons. Discover the clinical evidence, optimal dosing, forms, and who benefits most from this Ayurvedic nootropic.
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Creatine for Brain Health: The Cognitive Benefits Your Longevity Stack Is Missing
Clinical evidence shows creatine monohydrate boosts cognitive performance under sleep deprivation, in vegetarians, and after TBI—far beyond its muscle reputation.
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Grip Strength as a Longevity Biomarker: What Your Handshake Predicts About Mortality
Grip strength is one of the most powerful predictors of all-cause mortality, cardiovascular disease, and cognitive decline. Here is what the evidence shows and what to do about it.
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Semax Dosage and Nasal Protocol: A Clinical Guide for Standard, NA-Semax, and the Amidate Form
Precise Semax dosing by variant — 0.1% standard, NA-Semax, NA-Semax Amidate — with cycling schedules, titration steps, and nasal administration technique.
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CDP-Choline (Citicoline): The Physician's Guide to Dosing, Evidence, and Clinical Use
A clinical review of CDP-choline (citicoline) for cognitive function, brain fog, and neuroprotection — with dosing protocols, mechanisms, and comparison to alpha-GPC.
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Methylene Blue Dosage Guide: Clinical Protocols, Forms, and Safety
Evidence-based methylene blue dosage guide covering cognitive, mitochondrial, and antimicrobial applications with safety protocols and contraindications.
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Nootropic Peptides: A Physician's Guide to Cognitive Enhancement
Compare the top nootropic peptides—Semax, Selank, Dihexa, Humanin, and DSIP—with clinical evidence, dosing protocols, and candidacy criteria from an integrative physician.
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Plasmalogens: The Brain Phospholipid Declining With Age (And How to Restore It)
Plasmalogen deficiency accelerates cognitive decline. Learn what these critical ether phospholipids do, why they drop with age, and the clinical evidence for supplementation.
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Klotho Protein: The Anti-Aging Hormone That Controls How Fast You Age
Klotho protein declines with age and predicts cognitive decline, kidney disease, and cardiovascular risk. Here's what the science says about boosting it.
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Pregnenolone: The Neurosteroid That Powers Memory, Mood, and Stress Resilience
Pregnenolone is the master precursor to all steroid hormones. Learn how declining levels affect cognition, stress response, and how to supplement safely under clinical guidance.
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L-Theanine: Evidence-Based Guide to Dosage, Benefits, and Synergistic Stacks
Clinical review of L-theanine: mechanisms, optimal dosing for anxiety, sleep, and cognitive performance, plus evidence-based stacking protocols for adult patients.
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Phosphatidylcholine: The Essential Phospholipid for Liver, Brain, and Cellular Health
Dr. Douwes explains how phosphatidylcholine supports liver detoxification, cognitive function, and cellular membrane integrity — and who needs it most.
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Alpha-GPC: The Physician's Guide to Choline for Cognitive Performance and Neuroprotection
Dr. med. univ. Julian Douwes reviews Alpha-GPC dosing, mechanisms, clinical evidence for brain performance, acetylcholine synthesis, and how it compares to other choline sources.
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Acetyl-L-Carnitine (ALCAR): Brain Health, Fatigue, and Neuropathy — A Physician's Review
Acetyl-L-Carnitine (ALCAR) supports mitochondrial energy, acetylcholine synthesis, and nerve repair. Dr. Douwes reviews the clinical evidence, dosing, and stacking strategies.
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Lithium Orotate: Neuroprotection, Mood Stability & Longevity
A physician's guide to lithium orotate microdosing — mechanisms of neuroprotection, evidence for mood stability, Alzheimer's prevention research, and safe dosing protocols.
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Creatine for Longevity and Brain Health: What the Evidence Actually Shows
Creatine does far more than build muscle. This physician-written guide covers creatine supplementation for longevity, cognitive health, and sarcopenia prevention.
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Shilajit: Fulvic Acid, Mitochondrial Energy, and Testosterone Support
A physician's clinical guide to shilajit — how fulvic acid drives mitochondrial energy, supports testosterone, and offers neuroprotective effects. Dosing, forms, and safety.
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Phosphatidylserine: Memory, Cortisol & Cognitive Aging
A physician's clinical guide to phosphatidylserine — how it supports memory, blunts cortisol, and slows cognitive aging. Evidence-based dosage and protocols.
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Rhodiola Rosea: Clinical Evidence for Fatigue, Cortisol, and Cognitive Performance
A physician's guide to Rhodiola rosea — how it modulates the HPA axis, reduces stress-related fatigue, and improves cognitive performance in clinical practice.
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Semax: The Nootropic Peptide That Amplifies BDNF and Protects the Brain
Semax is a synthetic ACTH-derived peptide that upregulates BDNF, enhances focus and memory, and offers neuroprotection — used clinically in Russia for decades.
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Clearing Brain Fog After Treatment: Recovery Timeline
What to expect during brain fog recovery after Lyme treatment — the multi-system recovery approach, realistic timelines, and evidence-based strategies.
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Neuropsychological Testing for Brain Fog: When and Why
When to get neuropsychological testing for brain fog. What the evaluation measures, how it differs from standard neurology exams, and what the results mean for treatment.
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Dihexa Dosage: Nootropic Protocol and Safety
Dihexa dosing guide by Dr. med. univ. Julian Douwes. Oral and subcutaneous protocols, the c-Met safety question, and why caution is warranted with this potent nootropic peptide.
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Brain Fog Treatment: A Physician's Complete Guide
Brain fog treatment options from neuroinflammation workup to neuromodulation. Causes include post-COVID, Lyme, MCAS, and mold. TPS, NAD+, and hyperbaric oxygen covered.
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Cognitive Performance Protocol
Evidence-based protocol for mental clarity, focus, and memory from a physician who treats cognitive dysfunction daily.
