Clinical Immunology
Moderate EvidenceThe microbiome-immune connection and mucosal immunity.
How specific probiotic strains shift Th2-dominant immune responses in allergic rhinitis, eczema, food allergy, and asthma — a clinical guide to strain selection and protocol design.
A physician's guide to lactoferrin—how this iron-binding glycoprotein modulates immunity, supports gut barrier integrity, and may benefit chronic illness patients.
Physician-reviewed urolithin A dosage guide: optimal dose from 500mg to 2g, timing, cycling, and stacking protocols backed by clinical evidence.
Dr. Douwes reviews the clinical evidence on collagen peptides—types I, II, and III, joint cartilage data, gut healing, skin aging, and how to dose effectively.
Discover how functional medicine addresses Hashimoto's thyroiditis beyond TSH levels—root causes, advanced testing, and evidence-based protocols to reduce antibodies and symptoms.
A physician's clinical guide to butyrate supplements: mechanisms, evidence for gut permeability and immunity, dosage protocols, and which patients benefit most.
L-glutamine is the intestinal lining's primary fuel source. Explore the clinical evidence for leaky gut, Lyme dysbiosis, post-COVID recovery, and optimal dosing protocols.
A physician's review of bovine colostrum supplements — immune IgA, growth factors, leaky gut, and how to use it clinically. Evidence-graded and protocol-ready.
Akkermansia muciniphila strengthens gut barrier integrity, improves metabolic markers, and predicts immunotherapy response. A clinical review of supplementation evidence.
Clinical guide to diagnosing and treating SIBO with functional medicine — breath testing, rifaximin vs herbal antimicrobials, diet, and relapse prevention.
Physician comparison of BPC-157 oral capsules versus subcutaneous injection — covering bioavailability, onset, dosing, and clinical use cases for each route.
Physician guide to evidence-based probiotic strain selection. Which specific strains work for IBS, bloating, immunity, mood, and vaginal health, with dosing and evidence grades.
Physician guide to choosing a probiotic supplement. CFU count myths, strain identification, delivery mechanisms, third-party testing, and what the label should tell you.
How the KPV tripeptide reduces gut inflammation. NF-kB inhibition, PepT1 uptake, IBD and colitis evidence, oral dosing, and clinical observations.
Physician guide to probiotics, prebiotics, postbiotics, and synbiotics. Definitions, mechanisms, when to use each, and how they work together for gut health.
Comparing GI-MAP qPCR stool testing with standard stool culture. Detection rates, pathogen coverage, clinical utility, and when each test is the right choice.
How Lyme disease disrupts the gut microbiome. Antibiotic-driven dysbiosis, Borrelia's effect on intestinal permeability, the Hopkins microbiome findings, and recovery strategies.
Practical guide to interpreting gut microbiome test results. Dysbiosis markers, keystone species, diversity metrics, and what your results actually mean for treatment.
How gut microbial diversity shapes immune function, and what testing and restoration strategies the evidence supports. By Dr. Julian Douwes.
Why histamine intolerance is a systemic condition, not just allergies. Mechanisms, diagnostic pitfalls, gut-immune connections, and treatment strategies from clinical experience.
What microbiome stool tests measure, how to interpret results, and which tests provide actionable clinical information. By Dr. Julian Douwes.
Why 70% of your immune tissue lives in the gut, and what this means for health, autoimmunity, and treatment. By Dr. Julian Douwes.
Evidence-based guide to probiotic strain selection. Which strains work for which conditions, when to avoid probiotics, CFU counts, spore-based vs traditional, and what I use in clinical practice.
A structured four-phase protocol for gut restoration -- remove, repair, reinoculate, maintain. Evidence-based by Dr. Julian Douwes.
How BPC-157, KPV, and LL-37 support gastrointestinal repair. Dr. Julian Douwes explains peptide protocols for IBD, leaky gut, and gut barrier dysfunction.
The bidirectional gut-brain axis governs mood, cognition, and immune balance. Dr. Julian Douwes explains the science and integrative protocols for restoring this critical communication pathway.
