Oral Peptide Delivery in 2026: How Icotrokinra's FDA Approval Rewrites the Rules
The first oral targeted peptide approved for psoriasis signals a new era. Here is what the science of oral peptide delivery means for integrative medicine.
Longevity Medicine
Moderate EvidenceNAD+ Therapy
Nicotinamide adenine dinucleotide IV infusions and precursors for cellular energy restoration.
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5-Amino-1MQ: The NNMT Inhibitor With No Human Data
5-Amino-1MQ blocks NNMT, raising NAD+ and suppressing fat storage in mice. The rodent evidence is strong and consistent. Human trials: zero. What that means in practice.
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Gonadorelin: GnRH, Pulse Timing, and the hCG Substitution Problem
Gonadorelin is native GnRH with a 2 to 20 minute half-life. Why pulse frequency decides whether it stimulates or suppresses, plus trials, dosing and law.
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Fadogia Agrestis: Testosterone Support, Dosage, and Safety Concerns
Fadogia Agrestis has gained popularity as a natural testosterone booster, but the evidence is thin and safety signals warrant caution. A physician's honest review.
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Methylene Blue Drug Interactions: Serotonin Syndrome Risk and What to Avoid
Methylene blue is a potent MAOI that can trigger life-threatening serotonin syndrome. Learn which medications are dangerous to combine and clinical safety protocols.
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Kisspeptin: The Master Hormone Peptide for LH, Testosterone, and Fertility
Clinical guide to kisspeptin peptide therapy — how it stimulates LH and FSH, restores testosterone, supports fertility, and compares to HCG and enclomiphene.
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NAD+ IV Therapy Contraindications: Who Should Avoid It and Why
A physician's guide to NAD+ IV therapy contraindications — cancer history, active infections, G6PD deficiency, cardiac conditions, and pregnancy.
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NAD IV Infusion: What to Expect During Your First Session
Dr. med. univ. Julian Douwes walks through NAD IV therapy from pre-session prep to post-infusion recovery — what sensations are normal, and when to flag concerns.
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Pterostilbene vs Resveratrol: Which Stilbene Is Better for Longevity?
Pterostilbene offers 4× greater bioavailability than resveratrol with longer half-life. Compare clinical evidence, dosing, and Dr. Douwes's protocol for stilbene supplementation.
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Mitochondrial Dysfunction: Root Causes, Testing, and Evidence-Based Treatment
How mitochondrial dysfunction drives fatigue, brain fog, and chronic illness — plus clinical testing and protocols to restore cellular energy production.
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Hydrogen Water Benefits: What the Clinical Evidence Actually Shows
A physician's review of molecular hydrogen water — mechanisms, clinical trial data, dosing, and how it fits a longevity protocol. Evidence-based, hype-free.
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Mitophagy: How to Activate Your Cells' Self-Cleaning System for Longevity
Mitophagy removes damaged mitochondria to protect energy, cognition, and lifespan. A physician explains what activates it, what blocks it, and how to optimize it.
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PQQ Supplement: Mitochondrial Biogenesis, Brain Health & Clinical Dosing Guide
Pyrroloquinoline quinone (PQQ) promotes mitochondrial biogenesis, neuroprotection, and cellular energy. Dr. Douwes reviews the evidence and clinical dosing protocols.
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Circadian Rhythm Optimization: The Longevity Lever Most Physicians Overlook
How aligning your biological clock with light, food, and movement extends healthspan — evidence-based strategies from a longevity physician's clinical practice.
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Sirtuins & NAD+: The Longevity Proteins Every Physician Should Know
A physician's guide to sirtuins—the NAD+-dependent enzymes that regulate aging, metabolism, DNA repair, and inflammation across every organ system.
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Apigenin Supplement Benefits: NAD+ Booster, Senolytic & Sleep Aid
Apigenin inhibits CD38 to raise NAD+ levels, clears senescent cells, and deepens sleep. A physician's evidence-based guide to dosing, stacking, and safety.
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NMN Supplement: A Physician's Evidence-Based Dosing Guide
Clinical review of NMN supplementation: mechanisms, human trial data, optimal dosing (250–1,000 mg/day), forms ranked by bioavailability, and candidacy criteria.
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Sulforaphane and NRF2: The Clinical Case for Broccoli's Most Powerful Compound
Sulforaphane activates the NRF2 pathway to upregulate cellular defenses. A physician's review of clinical evidence, bioavailability, and dosing strategies.
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Alpha-Ketoglutarate (AKG): A Physician's Guide to the Longevity Molecule
Dr. med. univ. Julian Douwes reviews the evidence on alpha-ketoglutarate (AKG) supplementation — from TCA cycle biochemistry to epigenetic aging and clinical dosing.
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Resveratrol and Longevity: What the Clinical Evidence Actually Shows
A physician's review of resveratrol's SIRT1 activation, cardiovascular and neuroprotective data, bioavailability limits, and practical dosing for longevity.
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NAD Supplement Guide: NMN, NR, NADH and Oral NAD+ Precursors Compared
A physician's comparison of every oral NAD+ precursor — NMN, NR, NADH, and NAD3 — covering mechanisms, dosing, cofactors, and when to upgrade to IV therapy.
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NAD+ IV Side Effects: What to Expect and How to Manage Them
A physician's guide to NAD+ IV therapy side effects: what causes them, which are common vs serious, how to minimize discomfort, and who should avoid treatment.
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Anti-Aging Supplements: A Physician's Actual Stack for Longevity
A practicing physician's evidence-based anti-aging supplement stack. NAD+, resveratrol, CoQ10, omega-3, vitamin D — what works, what's overhyped, and what I actually take.
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NAD+ Injections vs Oral Supplements: Which Delivery Method Works?
NAD+ IV injections vs oral NMN vs sublingual NAD+ compared. Bioavailability data, clinical outcomes, cost analysis, and what I recommend in practice.
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NAD+ IV vs NMN vs NR: Which NAD Precursor Is Best?
NAD+ IV, NMN, and NR compared by a physician. Bioavailability, evidence, cost, and who benefits from which approach based on clinical experience.
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Epithalon vs NMN: Anti-Aging Mechanisms Compared
Epithalon vs NMN comparison by Dr. med. univ. Julian Douwes. Telomere lengthening vs NAD+ replenishment — different aging hallmarks, different evidence, and when to use each.
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NAD+ IV Therapy: Cellular Energy and Aging
How NAD+ IV therapy supports mitochondrial function and cellular repair. Evidence, clinical experience, and what patients should know.
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Building Your Longevity Stack
Evidence-tiered approach to longevity supplements. What works, what might work, and what to skip -- from a physician's perspective.
