Alpha-Ketoglutarate (AKG): A Physician's Guide to the Longevity Molecule
Dr. Julian Douwes reviews the evidence on alpha-ketoglutarate (AKG) supplementation — from TCA cycle biochemistry to epigenetic aging and clinical dosing.
Longevity Medicine
Moderate EvidenceNAD+ Therapy
Nicotinamide adenine dinucleotide IV infusions and precursors for cellular energy restoration.
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Resveratrol and Longevity: What the Clinical Evidence Actually Shows
A physician's review of resveratrol's SIRT1 activation, cardiovascular and neuroprotective data, bioavailability limits, and practical dosing for longevity.
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NAD Supplement Guide: NMN, NR, NADH and Oral NAD+ Precursors Compared
A physician's comparison of every oral NAD+ precursor — NMN, NR, NADH, and NAD3 — covering mechanisms, dosing, cofactors, and when to upgrade to IV therapy.
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NAD+ IV Side Effects: What to Expect and How to Manage Them
A physician's guide to NAD+ IV therapy side effects: what causes them, which are common vs serious, how to minimize discomfort, and who should avoid treatment.
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Anti-Aging Supplements: A Physician's Actual Stack for Longevity
A practicing physician's evidence-based anti-aging supplement stack. NAD+, resveratrol, CoQ10, omega-3, vitamin D — what works, what's overhyped, and what I actually take.
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NAD+ Injections vs Oral Supplements: Which Delivery Method Works?
NAD+ IV injections vs oral NMN vs sublingual NAD+ compared. Bioavailability data, clinical outcomes, cost analysis, and what I recommend in practice.
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NAD+ IV vs NMN vs NR: Which NAD Precursor Is Best?
NAD+ IV, NMN, and NR compared by a physician. Bioavailability, evidence, cost, and who benefits from which approach based on clinical experience.
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Epithalon vs NMN: Anti-Aging Mechanisms Compared
Epithalon vs NMN comparison by Dr. Julian Douwes. Telomere lengthening vs NAD+ replenishment — different aging hallmarks, different evidence, and when to use each.
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NAD+ IV Therapy: Cellular Energy and Aging
How NAD+ IV therapy supports mitochondrial function and cellular repair. Evidence, clinical experience, and what patients should know.
