Cortagen (AEDP): Brain Bioregulator and Nerve-Repair Data
Cortagen (Ala-Glu-Asp-Pro) is a Khavinson brain-cortex tetrapeptide. Rat nerve-regeneration and ischaemia data exist; human evidence is an unpublished claim.
Longevity Medicine
Brain Health
Plasmalogens: The Brain Phospholipid Declining With Age (And How to Restore It). Part of the Longevity Medicine library by Dr. med. univ. Julian Douwes
01
02
Brain Aging and Cognitive Reserve: What Is Established, What Is Emerging
What protects the aging brain? Risk factors and lifestyle trials vs zoster-vaccine signals and neuromodulation, each graded by strength of evidence.
03
Transcranial Pulse Stimulation (TPS): What the Evidence Shows
TPS is CE-marked for Alzheimer's in the EU, but its 2025 sham-controlled RCT missed its primary endpoint. How it works, what trials show, who it suits.
04
GLP-1 Agonists and Alzheimer's Prevention: What the Evidence Shows in 2026
Semaglutide and tirzepatide do more than control weight. Here's what the clinical evidence shows about GLP-1 agonists for cognitive protection and Alzheimer's risk reduction.
05
Vitamin D as a Neuroimmune Signal: Mental Health Applications Beyond Bone
How vitamin D acts as a lifespan neuroimmune signal in psychiatry — from depression and schizophrenia to autism and cognitive decline. Clinical dosing and evidence.
06
Creatine for Brain Health: The Cognitive Benefits Your Longevity Stack Is Missing
Clinical evidence shows creatine monohydrate boosts cognitive performance under sleep deprivation, in vegetarians, and after TBI—far beyond its muscle reputation.
07
Plasmalogens: The Brain Phospholipid Declining With Age (And How to Restore It)
Plasmalogen deficiency accelerates cognitive decline. Learn what these critical ether phospholipids do, why they drop with age, and the clinical evidence for supplementation.
08
Pregnenolone: The Neurosteroid That Powers Memory, Mood, and Stress Resilience
Pregnenolone is the master precursor to all steroid hormones. Learn how declining levels affect cognition, stress response, and how to supplement safely under clinical guidance.
09
PQQ Supplement: Mitochondrial Biogenesis, Brain Health & Clinical Dosing Guide
Pyrroloquinoline quinone (PQQ) promotes mitochondrial biogenesis, neuroprotection, and cellular energy. Dr. Douwes reviews the evidence and clinical dosing protocols.
10
Phosphatidylcholine: The Essential Phospholipid for Liver, Brain, and Cellular Health
Dr. Douwes explains how phosphatidylcholine supports liver detoxification, cognitive function, and cellular membrane integrity — and who needs it most.
11
Alpha-GPC: The Physician's Guide to Choline for Cognitive Performance and Neuroprotection
Dr. med. univ. Julian Douwes reviews Alpha-GPC dosing, mechanisms, clinical evidence for brain performance, acetylcholine synthesis, and how it compares to other choline sources.
12
The Glymphatic System: How Sleep Cleans Your Brain — And What Happens When It Doesn't
The brain's waste-clearance network runs almost exclusively during deep sleep. Learn what the glymphatic system is, how it removes toxic proteins, and how to optimise it clinically.
13
Acetyl-L-Carnitine (ALCAR): Brain Health, Fatigue, and Neuropathy — A Physician's Review
Acetyl-L-Carnitine (ALCAR) supports mitochondrial energy, acetylcholine synthesis, and nerve repair. Dr. Douwes reviews the clinical evidence, dosing, and stacking strategies.
14
Lithium Orotate: Neuroprotection, Mood Stability & Longevity
A physician's guide to lithium orotate microdosing — mechanisms of neuroprotection, evidence for mood stability, Alzheimer's prevention research, and safe dosing protocols.
15
Creatine for Longevity and Brain Health: What the Evidence Actually Shows
Creatine does far more than build muscle. This physician-written guide covers creatine supplementation for longevity, cognitive health, and sarcopenia prevention.
16
Phosphatidylserine: Memory, Cortisol & Cognitive Aging
A physician's clinical guide to phosphatidylserine — how it supports memory, blunts cortisol, and slows cognitive aging. Evidence-based dosage and protocols.
17
Semax: The Nootropic Peptide That Amplifies BDNF and Protects the Brain
Semax is a synthetic ACTH-derived peptide that upregulates BDNF, enhances focus and memory, and offers neuroprotection — used clinically in Russia for decades.
18
Peptide Therapy Benefits: A Physician's Evidence-Based Overview
Dr. Douwes reviews the clinically relevant benefits of peptide therapy — from tissue repair and immune modulation to longevity and brain health. What evidence supports each claim.
19
Magnesium Glycinate vs. L-Threonate: Which Form for Sleep, Anxiety, and Brain Health?
Physician comparison of magnesium glycinate vs magnesium L-threonate. Which form for sleep, which for cognition, absorption differences, dosing, and evidence quality.
