Clinical Immunology

Moderate Evidence

Autoimmunity

Molecular mimicry, tolerance breakdown, and integrative approaches to autoimmune conditions.

16 articles · 129 min total
01

Low-Dose Naltrexone for Ankylosing Spondylitis: Clinical Evidence and Protocol

How LDN modulates neuroinflammation and opioid-growth-factor signaling in ankylosing spondylitis. Evidence review, dosing protocol, and what patients can expect — from a physician perspective.

Low-Dose Naltrexone for Ankylosing Spondylitis: Clinical Evidence and Protocol
02

LDN Titration Schedule: How to Start, Dose, and Optimise Low-Dose Naltrexone

Step-by-step LDN titration guide covering starting dose, weekly escalation, timing, common side effects during ramp-up, and when to pause or plateau.

LDN Titration Schedule: How to Start, Dose, and Optimise Low-Dose Naltrexone
03

Ozone Therapy for Autoimmune Disease: Evidence, Patient Selection, and Integration

How medical ozone modulates immune dysregulation in rheumatoid arthritis, lupus, multiple sclerosis, and Hashimoto's — with protocols, contraindications, and outcome data.

Ozone Therapy for Autoimmune Disease: Evidence, Patient Selection, and Integration
04

Black Seed Oil (Nigella Sativa): Thymoquinone's Role in Immune Balance and Inflammation

A physician's evidence-based guide to black seed oil and thymoquinone—dosing, mechanisms, clinical uses in MCAS, autoimmunity, and metabolic health, plus who should avoid it.

Black Seed Oil (Nigella Sativa): Thymoquinone's Role in Immune Balance and Inflammation
05

Low-Dose Naltrexone for Lupus (SLE): Evidence, Dosing, and Clinical Considerations

LDN modulates TLR4 signaling and reduces type-I interferon activity in SLE. Review the clinical evidence, dosing titration, flare monitoring, and drug interactions.

Low-Dose Naltrexone for Lupus (SLE): Evidence, Dosing, and Clinical Considerations
06

Low Dose Naltrexone for Psoriatic Arthritis: Evidence, Protocols, and Clinical Insights

How LDN modulates opioid growth factor receptors and neuroinflammation to reduce psoriatic arthritis joint pain and skin flares — dosing, evidence, and who benefits most.

Low Dose Naltrexone for Psoriatic Arthritis: Evidence, Protocols, and Clinical Insights
07

Who Should NOT Take Ashwagandha: Contraindications, Drug Interactions & Safety Guide

Ashwagandha is generally well-tolerated, but specific groups face real risks. A physician reviews thyroid effects, autoimmune concerns, drug interactions, and who to avoid it.

Who Should NOT Take Ashwagandha: Contraindications, Drug Interactions & Safety Guide
08

Psoriasis: An Integrative Medicine Protocol

A functional medicine approach to psoriasis addressing gut-skin axis, immune modulation, LDN, photobiomodulation, and dietary strategies—backed by clinical evidence.

Psoriasis: An Integrative Medicine Protocol
09

Low Dose Naltrexone for Hashimoto's Thyroiditis: Clinical Evidence and Protocol

How LDN modulates thyroid autoimmunity, reduces TPO antibodies, and improves symptoms in Hashimoto's. Dosing protocols, mechanisms, and patient selection criteria.

Low Dose Naltrexone for Hashimoto's Thyroiditis: Clinical Evidence and Protocol
10

Therapeutic Apheresis: New Indications and Emerging Evidence in 2026

A clinical review of therapeutic apheresis beyond established autoimmune uses—covering neurological, metabolic, and post-infectious indications supported by 2025-2026 evidence.

Therapeutic Apheresis: New Indications and Emerging Evidence in 2026
11

Vagus Nerve Stimulation for Rheumatoid Arthritis: Clinical Evidence and Patient Selection

VNS in rheumatoid arthritis — RESET-RA trial results, patient selection criteria, integration with DMARDs, and how bioelectronic medicine is reshaping RA treatment.

Vagus Nerve Stimulation for Rheumatoid Arthritis: Clinical Evidence and Patient Selection
12

Hashimoto's Thyroiditis: A Functional Medicine Approach to Root-Cause Treatment

Discover how functional medicine addresses Hashimoto's thyroiditis beyond TSH levels—root causes, advanced testing, and evidence-based protocols to reduce antibodies and symptoms.

Hashimoto's Thyroiditis: A Functional Medicine Approach to Root-Cause Treatment
13

Peptides for Autoimmune Disease: A Physician's Evidence-Based Guide

Discover how immunomodulatory peptides like Thymosin Alpha-1, BPC-157, and LL-37 can help regulate immune dysfunction in autoimmune conditions. Clinical protocols and evidence.

Peptides for Autoimmune Disease: A Physician's Evidence-Based Guide
14

Low-Dose Naltrexone (LDN): Clinical Evidence for Chronic Illness and Autoimmunity

Low-dose naltrexone modulates immune function and reduces neuroinflammation. Evidence-based overview of LDN dosing, mechanisms, and clinical applications.

Low-Dose Naltrexone (LDN): Clinical Evidence for Chronic Illness and Autoimmunity
15

Apheresis for Autoimmune Disease: A Physician's Clinical Guide to Blood Purification Therapy

How extracorporeal apheresis reduces autoantibody burden, inflammatory cytokines, and immune complex load in treatment-resistant autoimmune conditions.

Apheresis for Autoimmune Disease: A Physician's Clinical Guide to Blood Purification Therapy
16

Autoimmune Disease: Mechanisms and Treatment

Why the immune system attacks itself, what triggers autoimmunity, and how integrative medicine approaches treatment. By Dr. Julian Douwes.

Autoimmune Disease: Mechanisms and Treatment
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