Foundational
Magnesium: 7 Forms Compared — Which One Do You Need?
Magnesium glycinate vs threonate vs taurate and 4 more forms compared. Dosing, deficiency signs, and why serum testing is unreliable. A physician's guide.
Longevity Medicine
Strong EvidenceSleep Science
Sleep architecture, circadian biology, and evidence-based optimization.
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Magnesium Forms Explained: Glycinate, Threonate, Malate, Citrate — Which Is Right for You?
A physician-reviewed guide to the eight major magnesium forms — bioavailability, clinical targets, dosing, and who should avoid which type.
03
Photobiomodulation and Sleep Quality: Mechanisms, Evidence, and Clinical Protocol
How red and near-infrared light therapy modulates circadian rhythm, melatonin, and slow-wave sleep — with dosing protocol and patient selection criteria.
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Creatine for Brain Health: The Cognitive Benefits Your Longevity Stack Is Missing
Clinical evidence shows creatine monohydrate boosts cognitive performance under sleep deprivation, in vegetarians, and after TBI—far beyond its muscle reputation.
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5-HTP and Tryptophan: A Physician's Guide to Serotonin Precursors for Sleep, Mood, and Brain Fog
Dr. Julian Douwes explains 5-HTP vs tryptophan for serotonin support — dosing, safety, interactions, and clinical use in Lyme disease and post-COVID patients.
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L-Theanine: Evidence-Based Guide to Dosage, Benefits, and Synergistic Stacks
Clinical review of L-theanine: mechanisms, optimal dosing for anxiety, sleep, and cognitive performance, plus evidence-based stacking protocols for adult patients.
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Glycine: The Amino Acid Behind Better Sleep, Collagen, and Longevity
Glycine at 3 g before bed improves sleep quality in RCTs. As a longevity molecule it drives collagen synthesis, glutathione via GlyNAC, and mTOR modulation.
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Melatonin: Complete Dosing and Benefits Guide
A physician's evidence-based guide to melatonin dosing, timing, forms, and benefits beyond sleep — including longevity, immunity, and cancer biology.
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Circadian Rhythm Optimization: The Longevity Lever Most Physicians Overlook
How aligning your biological clock with light, food, and movement extends healthspan — evidence-based strategies from a longevity physician's clinical practice.
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Apigenin Supplement Benefits: NAD+ Booster, Senolytic & Sleep Aid
Apigenin inhibits CD38 to raise NAD+ levels, clears senescent cells, and deepens sleep. A physician's evidence-based guide to dosing, stacking, and safety.
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The Glymphatic System: How Sleep Cleans Your Brain — And What Happens When It Doesn't
The brain's waste-clearance network runs almost exclusively during deep sleep. Learn what the glymphatic system is, how it removes toxic proteins, and how to optimise it clinically.
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Ipamorelin: A Physician's Guide to Dosage, Benefits, and Clinical Use
Ipamorelin selectively amplifies GH pulses without raising cortisol or prolactin. Physician guide to dosing, stacking with CJC-1295, and candidacy.
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PEMF Frequency Guide: Which Hz Settings Treat Which Conditions
Physician's guide to PEMF frequency selection—from 1 Hz sleep protocols to 100 Hz inflammation reduction. Know which settings match your condition.
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Magnesium for Sleep: Which Form Works Best and Why
Dr. Julian Douwes reviews the clinical evidence on magnesium for sleep — comparing glycinate, threonate, and oxide, with dosing protocols used in integrative practice.
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DSIP Dosage and Protocol for Sleep
Evidence-based DSIP dosing guide for sleep. Subcutaneous protocols, timing, cycling, and realistic expectations from Dr. Julian Douwes.
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DSIP vs Melatonin: Which Sleep Peptide?
DSIP vs melatonin comparison by Dr. Julian Douwes. Sleep architecture modulation vs circadian timing — mechanisms, evidence levels, and when to use each.
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Magnesium Glycinate vs. L-Threonate: Which Form for Sleep, Anxiety, and Brain Health?
Physician comparison of magnesium glycinate vs magnesium L-threonate. Which form for sleep, which for cognition, absorption differences, dosing, and evidence quality.
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When to Take Magnesium: Morning vs. Night, With or Without Food
Physician guide to magnesium supplement timing. When to take glycinate, threonate, citrate, and other forms for maximum absorption and effect. Morning vs night, food interactions.
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Sleep Optimization Protocol
Evidence-based strategies for improving sleep quality -- environment, timing, supplements, and habits. By Dr. Julian Douwes.
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Sleep Architecture and Longevity
How sleep stages affect aging, recovery, and healthspan. Optimization strategies grounded in evidence and clinical experience.
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How Much Deep Sleep and REM Do You Need? Sleep Architecture Explained
Physician guide to sleep stages, deep sleep and REM targets by age, and what your sleep tracker data actually means for longevity and cognitive health.
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Best Supplements for Deep Sleep: Evidence Ranked
Physician-ranked guide to sleep supplements. Magnesium glycinate, glycine, apigenin, L-theanine, and ashwagandha compared by evidence quality for deep sleep enhancement.
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How to Increase Deep Sleep Naturally: A Physician's Protocol
Evidence-based protocol to increase deep sleep and slow-wave sleep. Temperature, light, exercise timing, supplements, and what actually works according to sleep research.
