Longevity Medicine
Emerging EvidenceEpigenetic clocks, telomere testing, and tracking your rate of aging.
Your genes are the piano you were given; epigenetics decides what gets played. What APOE4, twin studies and epigenetic clocks show about how much your DNA decides, and what you can influence.
The 12 hallmarks of aging from the 2023 López-Otín update: what each one is, whether it can be measured today, and how strong the evidence is for each intervention.
A physician's checklist for distinguishing genuine evidence-based longevity medicine from expensive wellness marketing — what to test, ask, and avoid.
Livagen (Lys-Glu-Asp-Ala) is a Khavinson liver tetrapeptide. Data are test-tube chromatin studies in elderly lymphocytes and rat work; no human trials.
Dr. med. univ. Julian Douwes reviews Russian short-chain peptide bioregulators — Thymalin, Pinealon, Cortagen, Ventfort — and the Khavinson protocol's evidence for longevity.
Trained immunity is epigenetic reprogramming of innate immune cells that boosts long-term pathogen defence without T or B cells. Here is what it means clinically.
Head-to-head comparison of the top commercial biological age tests — TruAge, GlycanAge, and OMICmAge — to help you choose the right panel for your longevity goals.
A physician's guide to sirtuins—the NAD+-dependent enzymes that regulate aging, metabolism, DNA repair, and inflammation across every organ system.
Dr. med. univ. Julian Douwes reviews the evidence on alpha-ketoglutarate (AKG) supplementation — from TCA cycle biochemistry to epigenetic aging and clinical dosing.
Dr. Douwes reviews hyperbaric oxygen therapy (HBOT): how it works, what the clinical evidence says for longevity, post-COVID, Lyme, and neurological recovery.
Evidence-based Epithalon dosing guide. Injection protocols, 10-20 day cycling, annual scheduling, and telomere monitoring from Dr. med. univ. Julian Douwes.
Evidence-based review of intermittent fasting for longevity. Autophagy activation, metabolic health, biological age, and what I recommend in clinical practice.
What telomere length means for aging, whether you can influence it, and the honest truth about telomerase activators and Epithalon.
What blood markers to test for longevity optimization, why standard panels are insufficient, and how to interpret results in context.
Epigenetic clocks, pace of aging, and how to measure how fast you are actually aging. What the tests mean and their limitations.
