Foundational
The 12 Hallmarks of Aging: A Physician's Framework
All 12 hallmarks of aging from the 2023 Lopez-Otin update, explained through clinical practice. What each hallmark is, how to measure it, and what interventions target it.
Longevity Medicine
Emerging EvidenceBiological Age Testing
Epigenetic clocks, telomere testing, and tracking your rate of aging.
01
02
Peptide Bioregulators: The Khavinson Protocol for Organ-Specific Regeneration
Dr. Julian Douwes reviews Russian short-chain peptide bioregulators — Thymalin, Pinealon, Cortagen, Ventfort — and the Khavinson protocol's evidence for longevity.
03
Trained Immunity: How Your Innate Immune System Develops Epigenetic Memory
Trained immunity is epigenetic reprogramming of innate immune cells that boosts long-term pathogen defence without T or B cells. Here is what it means clinically.
04
Epigenetic Clock Tests Compared: TruAge, GlycanAge, and OMICmAge
Head-to-head comparison of the top commercial biological age tests — TruAge, GlycanAge, and OMICmAge — to help you choose the right panel for your longevity goals.
05
Sirtuins & NAD+: The Longevity Proteins Every Physician Should Know
A physician's guide to sirtuins—the NAD+-dependent enzymes that regulate aging, metabolism, DNA repair, and inflammation across every organ system.
06
Alpha-Ketoglutarate (AKG): A Physician's Guide to the Longevity Molecule
Dr. Julian Douwes reviews the evidence on alpha-ketoglutarate (AKG) supplementation — from TCA cycle biochemistry to epigenetic aging and clinical dosing.
07
Hyperbaric Oxygen Therapy for Longevity and Recovery: A Physician's Review
Dr. Douwes reviews hyperbaric oxygen therapy (HBOT): how it works, what the clinical evidence says for longevity, post-COVID, Lyme, and neurological recovery.
08
Epithalon Dosage: Telomere Protocol and Cycling
Evidence-based Epithalon dosing guide. Injection protocols, 10-20 day cycling, annual scheduling, and telomere monitoring from Dr. Julian Douwes.
09
Intermittent Fasting for Longevity: What the Evidence Supports
Evidence-based review of intermittent fasting for longevity. Autophagy activation, metabolic health, biological age, and what I recommend in clinical practice.
10
Telomere Health: Length, Telomerase, Epithalon
What telomere length means for aging, whether you can influence it, and the honest truth about telomerase activators and Epithalon.
11
Biological Age Testing
Epigenetic clocks, pace of aging, and how to measure how fast you are actually aging. What the tests mean and their limitations.
