Clinical Immunology

Moderate Evidence

Immune Modulation

Restoring immune balance through targeted intervention rather than suppression.

18 articles · 153 min total
01

Ozone Therapy for Autoimmune Disease: Evidence, Patient Selection, and Integration

How medical ozone modulates immune dysregulation in rheumatoid arthritis, lupus, multiple sclerosis, and Hashimoto's — with protocols, contraindications, and outcome data.

Ozone Therapy for Autoimmune Disease: Evidence, Patient Selection, and Integration
02

Black Seed Oil (Nigella Sativa): Thymoquinone's Role in Immune Balance and Inflammation

A physician's evidence-based guide to black seed oil and thymoquinone—dosing, mechanisms, clinical uses in MCAS, autoimmunity, and metabolic health, plus who should avoid it.

Black Seed Oil (Nigella Sativa): Thymoquinone's Role in Immune Balance and Inflammation
03

Low-Dose Naltrexone for Lupus (SLE): Evidence, Dosing, and Clinical Considerations

LDN modulates TLR4 signaling and reduces type-I interferon activity in SLE. Review the clinical evidence, dosing titration, flare monitoring, and drug interactions.

Low-Dose Naltrexone for Lupus (SLE): Evidence, Dosing, and Clinical Considerations
04

Low Dose Naltrexone for Psoriatic Arthritis: Evidence, Protocols, and Clinical Insights

How LDN modulates opioid growth factor receptors and neuroinflammation to reduce psoriatic arthritis joint pain and skin flares — dosing, evidence, and who benefits most.

Low Dose Naltrexone for Psoriatic Arthritis: Evidence, Protocols, and Clinical Insights
05

Low Dose Naltrexone for Hashimoto's Thyroiditis: Clinical Evidence and Protocol

How LDN modulates thyroid autoimmunity, reduces TPO antibodies, and improves symptoms in Hashimoto's. Dosing protocols, mechanisms, and patient selection criteria.

Low Dose Naltrexone for Hashimoto's Thyroiditis: Clinical Evidence and Protocol
06

Low-Dose Naltrexone for Multiple Sclerosis: Evidence, Dosing, and Clinical Considerations

A clinical guide to low-dose naltrexone (LDN) in multiple sclerosis: mechanisms, clinical trial data, dosing protocols, patient selection, and integration with DMTs.

Low-Dose Naltrexone for Multiple Sclerosis: Evidence, Dosing, and Clinical Considerations
07

Low Dose Naltrexone for Crohn's Disease and Ulcerative Colitis

How LDN modulates gut immunity, reduces inflammation, and offers a low-risk adjunct in IBD — dosing, evidence hierarchy, patient selection, and monitoring.

Low Dose Naltrexone for Crohn's Disease and Ulcerative Colitis
08

Ultraviolet Blood Irradiation (UVBI): A Physician's Clinical Protocol Guide

Dr. Julian Douwes explains UVBI therapy — mechanisms, clinical indications, treatment protocol, contraindications, and how it compares to IV laser and ozone.

Ultraviolet Blood Irradiation (UVBI): A Physician's Clinical Protocol Guide
09

Probiotics for Allergic Disease: From Adjunct Supplement to Immune-Modifying Strategy

How specific probiotic strains shift Th2-dominant immune responses in allergic rhinitis, eczema, food allergy, and asthma — a clinical guide to strain selection and protocol design.

Probiotics for Allergic Disease: From Adjunct Supplement to Immune-Modifying Strategy
10

Low-Dose Naltrexone for Long COVID and Post-Viral Fatigue: Clinical Evidence and Protocol

LDN reduces neuroinflammation and immune dysregulation driving long COVID fatigue. Clinical evidence, dosing protocol, and how LDN fits a multimodal recovery plan.

Low-Dose Naltrexone for Long COVID and Post-Viral Fatigue: Clinical Evidence and Protocol
11

Peptides for Autoimmune Disease: A Physician's Evidence-Based Guide

Discover how immunomodulatory peptides like Thymosin Alpha-1, BPC-157, and LL-37 can help regulate immune dysfunction in autoimmune conditions. Clinical protocols and evidence.

Peptides for Autoimmune Disease: A Physician's Evidence-Based Guide
12

Bovine Colostrum: Clinical Evidence for Immune Modulation and Gut Healing

A physician's review of bovine colostrum supplements — immune IgA, growth factors, leaky gut, and how to use it clinically. Evidence-graded and protocol-ready.

Bovine Colostrum: Clinical Evidence for Immune Modulation and Gut Healing
13

Peptide Therapy Benefits: A Physician's Evidence-Based Overview

Dr. Douwes reviews the clinically relevant benefits of peptide therapy — from tissue repair and immune modulation to longevity and brain health. What evidence supports each claim.

Peptide Therapy Benefits: A Physician's Evidence-Based Overview
14

Low-Dose Naltrexone (LDN): Clinical Evidence for Chronic Illness and Autoimmunity

Low-dose naltrexone modulates immune function and reduces neuroinflammation. Evidence-based overview of LDN dosing, mechanisms, and clinical applications.

Low-Dose Naltrexone (LDN): Clinical Evidence for Chronic Illness and Autoimmunity
15

Ozone Therapy vs. IV Laser Therapy: A Physician's Clinical Comparison

Dr. Douwes compares ozone therapy and IV laser therapy—mechanisms, clinical indications, safety profiles, and when to combine both in integrative practice.

Ozone Therapy vs. IV Laser Therapy: A Physician's Clinical Comparison
16

Hyperthermia for Cancer: Evidence, Protocols, and Clinical Experience

Hyperthermia cancer treatment evidence from RCTs and 35 years of clinical use. How moderate and extreme WBH synergize with chemo and radiation therapy.

Hyperthermia for Cancer: Evidence, Protocols, and Clinical Experience
17

Mistletoe Therapy (Iscador): Evidence in Integrative Oncology

Mistletoe extract (Iscador, Helixor) for cancer: mechanism, NK cell activation, quality of life evidence, injection protocols, and the German clinical tradition.

Mistletoe Therapy (Iscador): Evidence in Integrative Oncology
18

Immune Modulation: Enhancing or Calming Immunity

How physicians enhance weak immune responses and calm overactive ones. Evidence-based immune modulation explained by Dr. Julian Douwes.

Immune Modulation: Enhancing or Calming Immunity
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