Thymogen (Glu-Trp): Russian Drug, Failed Western Trial
Thymogen (Glu-Trp, oglufanide) is a licensed immunostimulant in Russia. The same dipeptide failed a US phase III trial in Kaposi sarcoma. Evidence and doses.
Clinical Immunology
Moderate EvidenceImmune Modulation
Restoring immune balance through targeted intervention rather than suppression.
01
02
Thymic Involution and Immune Aging: Can Peptides Help?
The thymus shrinks with age and naive T-cell output falls. What thymosin alpha-1 and the TRIIM study show, and what would count as real proof.
03
Thymosin Alpha-1 for Long COVID: Immune Restoration When the Immune System Stays Broken
How thymosin alpha-1 addresses the core immune dysfunction of long COVID — T-cell exhaustion, NK cell deficiency, and chronic viral persistence — with dosing protocols.
04
Ozone Therapy for Autoimmune Disease: Evidence, Patient Selection, and Integration
How medical ozone modulates immune dysregulation in rheumatoid arthritis, lupus, multiple sclerosis, and Hashimoto's — with protocols, contraindications, and outcome data.
05
Black Seed Oil (Nigella Sativa): Thymoquinone's Role in Immune Balance and Inflammation
A physician's evidence-based guide to black seed oil and thymoquinone—dosing, mechanisms, clinical uses in MCAS, autoimmunity, and metabolic health, plus who should avoid it.
06
Low-Dose Naltrexone for Lupus (SLE): Evidence, Dosing, and Clinical Considerations
LDN modulates TLR4 signaling and reduces type-I interferon activity in SLE. Review the clinical evidence, dosing titration, flare monitoring, and drug interactions.
07
Trained Immunity: How Your Innate Immune System Develops Epigenetic Memory
Trained immunity is epigenetic reprogramming of innate immune cells that boosts long-term pathogen defence without T or B cells. Here is what it means clinically.
08
Low Dose Naltrexone for Psoriatic Arthritis: Evidence, Protocols, and Clinical Insights
How LDN modulates opioid growth factor receptors and neuroinflammation to reduce psoriatic arthritis joint pain and skin flares — dosing, evidence, and who benefits most.
09
Low Dose Naltrexone for Hashimoto's Thyroiditis: Clinical Evidence and Protocol
How LDN modulates thyroid autoimmunity, reduces TPO antibodies, and improves symptoms in Hashimoto's. Dosing protocols, mechanisms, and patient selection criteria.
10
Low-Dose Naltrexone for Multiple Sclerosis: Evidence, Dosing, and Clinical Considerations
A clinical guide to low-dose naltrexone (LDN) in multiple sclerosis: mechanisms, clinical trial data, dosing protocols, patient selection, and integration with DMTs.
11
Low Dose Naltrexone for Crohn's Disease and Ulcerative Colitis
How LDN modulates gut immunity, reduces inflammation, and offers a low-risk adjunct in IBD — dosing, evidence hierarchy, patient selection, and monitoring.
12
Ultraviolet Blood Irradiation (UVBI): A Physician's Clinical Protocol Guide
Dr. med. univ. Julian Douwes explains UVBI therapy — mechanisms, clinical indications, treatment protocol, contraindications, and how it compares to IV laser and ozone.
13
Probiotics for Allergic Disease: From Adjunct Supplement to Immune-Modifying Strategy
How specific probiotic strains shift Th2-dominant immune responses in allergic rhinitis, eczema, food allergy, and asthma — a clinical guide to strain selection and protocol design.
14
Low-Dose Naltrexone for Long COVID and Post-Viral Fatigue: Clinical Evidence and Protocol
LDN reduces neuroinflammation and immune dysregulation driving long COVID fatigue. Clinical evidence, dosing protocol, and how LDN fits a multimodal recovery plan.
15
Peptides for Autoimmune Disease: A Physician's Evidence-Based Guide
Discover how immunomodulatory peptides like Thymosin Alpha-1, BPC-157, and LL-37 can help regulate immune dysfunction in autoimmune conditions. Clinical protocols and evidence.
16
Bovine Colostrum: Clinical Evidence for Immune Modulation and Gut Healing
A physician's review of bovine colostrum supplements — immune IgA, growth factors, leaky gut, and how to use it clinically. Evidence-graded and protocol-ready.
17
Peptide Therapy Benefits: A Physician's Evidence-Based Overview
Dr. Douwes reviews the clinically relevant benefits of peptide therapy — from tissue repair and immune modulation to longevity and brain health. What evidence supports each claim.
18
Low-Dose Naltrexone (LDN): Clinical Evidence for Chronic Illness and Autoimmunity
Low-dose naltrexone modulates immune function and reduces neuroinflammation. Evidence-based overview of LDN dosing, mechanisms, and clinical applications.
19
Ozone Therapy vs. IV Laser Therapy: A Physician's Clinical Comparison
Dr. Douwes compares ozone therapy and IV laser therapy—mechanisms, clinical indications, safety profiles, and when to combine both in integrative practice.
20
Hyperthermia for Cancer: Evidence, Protocols, and Clinical Experience
Hyperthermia cancer treatment evidence from RCTs and 35 years of clinical use. How moderate and extreme WBH synergize with chemo and radiation therapy.
21
How Vaccines Interact with the Immune System
An evidence-based explanation of how vaccines work immunologically, including adjuvants, memory, and individual variation. By Dr. med. univ. Julian Douwes.
22
Chronic Fatigue Syndrome: A Physician's Complete Guide
A physician's complete guide to chronic fatigue syndrome. Mitochondrial dysfunction, immune dysregulation, diagnostic criteria, and the stepwise treatment approach we use at St. George Hospital.
23
IV Laser Therapy and Immune Function
How intravenous laser therapy at different wavelengths affects immune cells. Evidence, mechanisms, and clinical applications by Dr. med. univ. Julian Douwes.
24
Innate vs. Adaptive Immunity Explained
How your two immune systems work together to defend against infection and disease. A clear explanation from Dr. med. univ. Julian Douwes.
25
Mistletoe Therapy (Iscador): Evidence in Integrative Oncology
Mistletoe extract (Iscador, Helixor) for cancer: mechanism, NK cell activation, quality of life evidence, injection protocols, and the German clinical tradition.
26
Immune Modulation: Enhancing or Calming Immunity
How physicians enhance weak immune responses and calm overactive ones. Evidence-based immune modulation explained by Dr. med. univ. Julian Douwes.
27
Integrative Oncology: What It Is and What It Is Not
A clinician's guide to integrative oncology. What complementary therapies have evidence, how they work alongside conventional treatment, and what 35 years of clinical experience at St. George Hospital have shown.
