Foundational
What Is TMS? Transcranial Magnetic Stimulation Explained
Transcranial magnetic stimulation explained by a physician. TMS vs TPS, FDA clearance, session protocols, and why I rank TPS as the top neuromodulation tool in my practice.
Clinical Protocols
Depression
Treatment-Resistant Depression: The Cause-First Workup Before TMS. Part of the Clinical Protocols library by Dr. med. univ. Julian Douwes
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At-Home Brain Stimulation for Depression: ProlivRx and Flow FL-100 — What the 2025–2026 FDA Approvals Mean for Patients
Two FDA-approved at-home brain stimulation devices for depression are now available. Here is what the clinical evidence says and when they are — or are not — the right choice.
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CRP and Depression: What Inflammation Testing Reveals Before You Start TMS
CRP and cytokine testing before TMS for depression identifies the inflamed subtype, predicts response, and guides whether inflammation must be treated first.
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Ketamine as a Bridge to TMS: The Induction Protocol for Treatment-Resistant Depression
When TMS for depression takes weeks to build effect, IV ketamine can bridge the gap — acute relief while circuits remodel. Protocol, evidence, and patient selection.
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Accelerated TMS in 2026: SWIFT, 5×5 rTMS, and Faster Routes to Depression Remission
SWIFT deep TMS and 5×5 accelerated rTMS compress depression treatment to 5–6 days. What the 2026 evidence shows, who qualifies, and how Julian positions these protocols.
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Treatment-Resistant Depression: The Cause-First Workup Before TMS
Before treating TRD, investigate the cause: qEEG brain mapping, CRP inflammation testing, Lyme/viral infections, and toxic relationships. Julian's clinical protocol.
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ECT Must Be Banned: A Treatment With No Going Back
A physician's case for banning electroconvulsive therapy: permanent memory loss, falling brain metabolism on PET and SPECT, high relapse, thin consent, and the targeted alternatives.
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PE-22-28 (Mini-Spadin): A TREK-1 Peptide Tested Only in Mice
PE-22-28 is a 7-amino-acid spadin analog that blocks the TREK-1 channel and acted as a fast antidepressant in mice. No human has received it in a study.
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Ketamine Infusion Therapy: Protocol, Evidence, and Who Benefits
A clinical guide to IV ketamine infusions for treatment-resistant depression and chronic pain — dosing, mechanism, patient selection, and realistic expectations.
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Vitamin D as a Neuroimmune Signal: Mental Health Applications Beyond Bone
How vitamin D acts as a lifespan neuroimmune signal in psychiatry — from depression and schizophrenia to autism and cognitive decline. Clinical dosing and evidence.
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Photobiomodulation for Depression: What the Clinical Evidence Actually Shows
Dr. Douwes reviews transcranial photobiomodulation for depression — mechanisms, clinical trial data, dosing protocols, and how it fits an integrative mental health strategy.
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TMS for Depression: What 20 Years of Evidence Shows
TMS depression treatment explained by a physician. FDA clearance history, rTMS protocols, theta burst stimulation, response rates, and who responds best.
