Spermidine vs Urolithin A: Two Autophagy Activators, One Longevity Stack
Spermidine and urolithin A both activate autophagy but through different pathways. A clinical comparison of mechanisms, evidence, dosing, and who benefits from one or both.
Longevity Medicine
Autophagy
Spermidine vs Urolithin A: Two Autophagy Activators, One Longevity Stack. Part of the Longevity Medicine library by Dr. med. univ. Julian Douwes
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Rapamycin and Liver Health: What mTOR Inhibition Does to Hepatic Metabolism
How rapamycin targets mTOR in the liver to reverse diet-induced metabolic stress, protect hepatocytes, and what this means for longevity patients with metabolic risk.
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mTOR Signaling and Longevity: The Pathway That Controls How Fast You Age
How mTOR drives cellular aging, which compounds inhibit it, and why targeting this pathway is central to modern longevity medicine. Clinical overview by Dr. med. univ. Julian Douwes.
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Rapamycin Dosing for Longevity: Protocols, Timing & Clinical Considerations
A physician's evidence-based guide to rapamycin dosing for longevity: weekly intermittent protocols, dose ranges, lab monitoring, and who should avoid it.
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Mitophagy: How to Activate Your Cells' Self-Cleaning System for Longevity
Mitophagy removes damaged mitochondria to protect energy, cognition, and lifespan. A physician explains what activates it, what blocks it, and how to optimize it.
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Fasting Mimicking Diet for Longevity: A Physician's Evidence Review
What the science says about the fasting mimicking diet, ProLon, autophagy, and whether a 5-day caloric restriction cycle belongs in a longevity protocol.
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Heat Shock Proteins: How Sauna, Exercise, and Hormesis Activate Cellular Repair
Heat shock proteins are the body's emergency repair crew. Learn how sauna, cold, and exercise trigger HSPs and why they matter for longevity and disease prevention.
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Hormesis: Why Controlled Stress Drives Longevity
Hormesis is the biological phenomenon where low-dose stressors trigger adaptive responses that strengthen resilience, slow aging, and extend healthspan. A physician's guide.
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Urolithin A: Activating Mitophagy for Muscle Health and Longevity
Dr. Douwes reviews urolithin A — the gut-derived metabolite that activates mitophagy, preserves muscle function, and extends healthspan in clinical trials.
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Spermidine and Longevity: The Autophagy Activator Your Cells Are Waiting For
Spermidine triggers cellular autophagy, protects cardiovascular and cognitive health, and extends lifespan in animal models. What the human evidence actually shows.
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Intermittent Fasting for Longevity: What the Evidence Supports
Evidence-based review of intermittent fasting for longevity. Autophagy activation, metabolic health, biological age, and what I recommend in clinical practice.
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Autophagy: How Your Body Recycles Damaged Cells
How to activate autophagy through fasting, exercise, and targeted interventions. The science of cellular self-cleaning, its role in aging, and what actually works.
