Diagnostics

Emerging Evidence

Functional Medicine Labs

Organic acids, methylation panels, oxidative stress markers, and specialty diagnostics.

22 articles · 185 min total
01

Interventions That Lower Epigenetic Age: What 41 Human Studies Actually Show

A 2026 systematic review of 41 trials identified which interventions genuinely lower next-generation epigenetic clocks — and which popular longevity staples have no detectable effect.

Interventions That Lower Epigenetic Age: What 41 Human Studies Actually Show
02

DMSA vs DMPS: Which Oral Chelating Agent Fits Your Heavy Metal Profile?

A physician's clinical comparison of DMSA and DMPS — mechanism, target metals, dosing, mineral depletion, and how to choose between the two oral chelators.

DMSA vs DMPS: Which Oral Chelating Agent Fits Your Heavy Metal Profile?
03

Trimethylglycine (TMG/Betaine): Methylation Support, Homocysteine, and Longevity

TMG donates methyl groups to lower homocysteine, support liver function, and enhance athletic performance. Clinical dosing, evidence, and who benefits most.

Trimethylglycine (TMG/Betaine): Methylation Support, Homocysteine, and Longevity
04

Epigenetic Clock Tests Compared: TruAge, GlycanAge, and OMICmAge

Head-to-head comparison of the top commercial biological age tests — TruAge, GlycanAge, and OMICmAge — to help you choose the right panel for your longevity goals.

Epigenetic Clock Tests Compared: TruAge, GlycanAge, and OMICmAge
05

Chelation Therapy Safety: Risks, Contraindications, and What to Monitor

A physician's guide to chelation therapy safety — covering EDTA, DMPS, and DMSA risks, contraindications, mineral depletion, and clinical monitoring protocols.

Chelation Therapy Safety: Risks, Contraindications, and What to Monitor
06

Benfotiamine for Peripheral Neuropathy: A Physician's Evidence Review

Fat-soluble thiamine that crosses cell membranes conventional B1 cannot. How benfotiamine repairs peripheral nerves, reduces oxidative stress, and supports recovery in Lyme, diabetes, and post-COVID neuropathy.

Benfotiamine for Peripheral Neuropathy: A Physician's Evidence Review
07

Hashimoto's Thyroiditis: A Functional Medicine Approach to Root-Cause Treatment

Discover how functional medicine addresses Hashimoto's thyroiditis beyond TSH levels—root causes, advanced testing, and evidence-based protocols to reduce antibodies and symptoms.

Hashimoto's Thyroiditis: A Functional Medicine Approach to Root-Cause Treatment
08

Homocysteine: What Your Levels Mean and How to Lower Them

High homocysteine quietly damages blood vessels and the brain. A physician explains optimal ranges, root causes like MTHFR, and evidence-based ways to lower it.

Homocysteine: What Your Levels Mean and How to Lower Them
09

Methylcobalamin vs. Cyanocobalamin: A Physician's Guide to B12 Supplementation

Dr. Douwes breaks down every B12 form — methylcobalamin, adenosylcobalamin, hydroxocobalamin — covering dosing, testing, and who truly benefits from active B12.

Methylcobalamin vs. Cyanocobalamin: A Physician's Guide to B12 Supplementation
10

Glycine: The Amino Acid Behind Better Sleep, Collagen, and Longevity

Glycine at 3 g before bed improves sleep quality in RCTs. As a longevity molecule it drives collagen synthesis, glutathione via GlyNAC, and mTOR modulation.

Glycine: The Amino Acid Behind Better Sleep, Collagen, and Longevity
11

POTS and Dysautonomia: A Functional Medicine Protocol

POTS and dysautonomia affect millions after infection or long COVID. This functional medicine protocol addresses root causes beyond symptom management.

POTS and Dysautonomia: A Functional Medicine Protocol
12

MTHFR Gene Mutation: Symptoms, Testing, and a Physician's Methylation Protocol

Dr. Douwes explains MTHFR gene variants, how they disrupt methylation and detox, which labs to run, and the evidence-based supplement protocol he uses clinically.

MTHFR Gene Mutation: Symptoms, Testing, and a Physician's Methylation Protocol
13

Zinc Supplement Guide: Immune Function, Testosterone & Wound Healing

A physician's evidence-based guide to zinc supplementation — covering dosing, forms, immune support, testosterone, wound healing, and who actually needs it.

Zinc Supplement Guide: Immune Function, Testosterone & Wound Healing
14

SIBO Treatment Protocol: A Functional Medicine Approach to Small Intestinal Bacterial Overgrowth

Clinical guide to diagnosing and treating SIBO with functional medicine — breath testing, rifaximin vs herbal antimicrobials, diet, and relapse prevention.

SIBO Treatment Protocol: A Functional Medicine Approach to Small Intestinal Bacterial Overgrowth
15

Rhodiola Rosea: Clinical Evidence for Fatigue, Cortisol, and Cognitive Performance

A physician's guide to Rhodiola rosea — how it modulates the HPA axis, reduces stress-related fatigue, and improves cognitive performance in clinical practice.

Rhodiola Rosea: Clinical Evidence for Fatigue, Cortisol, and Cognitive Performance
16

Heavy Metal Chelation Therapy: A Physician's Clinical Protocol

Dr. med. univ. Julian Douwes explains heavy metal chelation therapy — which agents to use, when to use them, how to prepare, and how to monitor safely in clinical practice.

Heavy Metal Chelation Therapy: A Physician's Clinical Protocol
17

Your First Consultation: What We Assess and Why

What happens during your first consultation at St. George Hospital. The labs we order, the intake process, how we build your treatment plan, and realistic timelines.

Your First Consultation: What We Assess and Why
18

Labs Your Doctor Won't Order (But Should)

Essential functional medicine labs most doctors skip. hs-CRP, fasting insulin, homocysteine, full thyroid, ApoB, and more — what to request and why it matters.

Labs Your Doctor Won't Order (But Should)
19

Organic Acids Test (OAT): What It Reveals

Complete guide to the Organic Acids Test. What the 70+ markers mean, what OAT reveals about mitochondrial function, neurotransmitters, and gut health, and when to order it.

Organic Acids Test (OAT): What It Reveals
20

Functional vs Conventional Lab Ranges: Why Yours Differ

Why functional medicine blood test ranges differ from conventional lab ranges. TSH, vitamin D, ferritin, fasting glucose — what 'normal' really means and why it matters.

Functional vs Conventional Lab Ranges: Why Yours Differ
21

Optimal vs Normal Lab Ranges: Why Your Doctor Says You're Fine

Why standard lab reference ranges miss early disease. Optimal ranges for TSH, ferritin, vitamin D, B12, fasting insulin, hsCRP, and why functional medicine testing matters.

Optimal vs Normal Lab Ranges: Why Your Doctor Says You're Fine
22

Functional Medicine Labs: OAT, DUTCH, GI-MAP

A clinical guide to organic acids testing, DUTCH hormone testing, and GI-MAP stool analysis -- what they measure and when to use them.

Functional Medicine Labs: OAT, DUTCH, GI-MAP
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