DMSA vs DMPS: Which Oral Chelating Agent Fits Your Heavy Metal Profile?
A physician's clinical comparison of DMSA and DMPS — mechanism, target metals, dosing, mineral depletion, and how to choose between the two oral chelators.
Diagnostics
Emerging EvidenceFunctional Medicine Labs
Organic acids, methylation panels, oxidative stress markers, and specialty diagnostics.
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Trimethylglycine (TMG/Betaine): Methylation Support, Homocysteine, and Longevity
TMG donates methyl groups to lower homocysteine, support liver function, and enhance athletic performance. Clinical dosing, evidence, and who benefits most.
03
Epigenetic Clock Tests Compared: TruAge, GlycanAge, and OMICmAge
Head-to-head comparison of the top commercial biological age tests — TruAge, GlycanAge, and OMICmAge — to help you choose the right panel for your longevity goals.
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Chelation Therapy Safety: Risks, Contraindications, and What to Monitor
A physician's guide to chelation therapy safety — covering EDTA, DMPS, and DMSA risks, contraindications, mineral depletion, and clinical monitoring protocols.
05
Benfotiamine for Peripheral Neuropathy: A Physician's Evidence Review
Fat-soluble thiamine that crosses cell membranes conventional B1 cannot. How benfotiamine repairs peripheral nerves, reduces oxidative stress, and supports recovery in Lyme, diabetes, and post-COVID neuropathy.
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Hashimoto's Thyroiditis: A Functional Medicine Approach to Root-Cause Treatment
Discover how functional medicine addresses Hashimoto's thyroiditis beyond TSH levels—root causes, advanced testing, and evidence-based protocols to reduce antibodies and symptoms.
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Homocysteine: What Your Levels Mean and How to Lower Them
High homocysteine quietly damages blood vessels and the brain. A physician explains optimal ranges, root causes like MTHFR, and evidence-based ways to lower it.
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Methylcobalamin vs. Cyanocobalamin: A Physician's Guide to B12 Supplementation
Dr. Douwes breaks down every B12 form — methylcobalamin, adenosylcobalamin, hydroxocobalamin — covering dosing, testing, and who truly benefits from active B12.
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Glycine: The Amino Acid Behind Better Sleep, Collagen, and Longevity
Glycine at 3 g before bed improves sleep quality in RCTs. As a longevity molecule it drives collagen synthesis, glutathione via GlyNAC, and mTOR modulation.
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POTS and Dysautonomia: A Functional Medicine Protocol
POTS and dysautonomia affect millions after infection or long COVID. This functional medicine protocol addresses root causes beyond symptom management.
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MTHFR Gene Mutation: Symptoms, Testing, and a Physician's Methylation Protocol
Dr. Douwes explains MTHFR gene variants, how they disrupt methylation and detox, which labs to run, and the evidence-based supplement protocol he uses clinically.
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Zinc Supplement Guide: Immune Function, Testosterone & Wound Healing
A physician's evidence-based guide to zinc supplementation — covering dosing, forms, immune support, testosterone, wound healing, and who actually needs it.
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SIBO Treatment Protocol: A Functional Medicine Approach to Small Intestinal Bacterial Overgrowth
Clinical guide to diagnosing and treating SIBO with functional medicine — breath testing, rifaximin vs herbal antimicrobials, diet, and relapse prevention.
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Rhodiola Rosea: Clinical Evidence for Fatigue, Cortisol, and Cognitive Performance
A physician's guide to Rhodiola rosea — how it modulates the HPA axis, reduces stress-related fatigue, and improves cognitive performance in clinical practice.
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Heavy Metal Chelation Therapy: A Physician's Clinical Protocol
Dr. Julian Douwes explains heavy metal chelation therapy — which agents to use, when to use them, how to prepare, and how to monitor safely in clinical practice.
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Labs Your Doctor Won't Order (But Should)
Essential functional medicine labs most doctors skip. hs-CRP, fasting insulin, homocysteine, full thyroid, ApoB, and more — what to request and why it matters.
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Organic Acids Test (OAT): What It Reveals
Complete guide to the Organic Acids Test. What the 70+ markers mean, what OAT reveals about mitochondrial function, neurotransmitters, and gut health, and when to order it.
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Functional vs Conventional Lab Ranges: Why Yours Differ
Why functional medicine blood test ranges differ from conventional lab ranges. TSH, vitamin D, ferritin, fasting glucose — what 'normal' really means and why it matters.
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Optimal vs Normal Lab Ranges: Why Your Doctor Says You're Fine
Why standard lab reference ranges miss early disease. Optimal ranges for TSH, ferritin, vitamin D, B12, fasting insulin, hsCRP, and why functional medicine testing matters.
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Functional Medicine Labs: OAT, DUTCH, GI-MAP
A clinical guide to organic acids testing, DUTCH hormone testing, and GI-MAP stool analysis -- what they measure and when to use them.
