Supplements
2 articles on Methylation by Dr. med. univ. Julian Douwes: Methylcobalamin vs. Cyanocobalamin: A Physician's Guide to B12 Supplementation; and more.
A 2026 systematic review of 41 trials identified which interventions genuinely lower next-generation epigenetic clocks — and which popular longevity staples have no detectable effect.
TMG donates methyl groups to lower homocysteine, support liver function, and enhance athletic performance. Clinical dosing, evidence, and who benefits most.
Head-to-head comparison of the top commercial biological age tests — TruAge, GlycanAge, and OMICmAge — to help you choose the right panel for your longevity goals.
High homocysteine quietly damages blood vessels and the brain. A physician explains optimal ranges, root causes like MTHFR, and evidence-based ways to lower it.
Dr. Douwes breaks down every B12 form — methylcobalamin, adenosylcobalamin, hydroxocobalamin — covering dosing, testing, and who truly benefits from active B12.
Glycine at 3 g before bed improves sleep quality in RCTs. As a longevity molecule it drives collagen synthesis, glutathione via GlyNAC, and mTOR modulation.
Dr. Douwes explains MTHFR gene variants, how they disrupt methylation and detox, which labs to run, and the evidence-based supplement protocol he uses clinically.
