Brain Aging and Cognitive Reserve: What Is Established, What Is Emerging
What protects the aging brain? Risk factors and lifestyle trials vs zoster-vaccine signals and neuromodulation, each graded by strength of evidence.
Neuromodulation
Brain Aging
2 articles on Brain Aging by Julian Douwes, M.D.: Brain Aging and Cognitive Reserve: What Is Established, What Is Emerging; and more.
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Transcranial Pulse Stimulation (TPS): What the Evidence Shows
TPS is CE-marked for Alzheimer's in the EU, but its 2025 sham-controlled RCT missed its primary endpoint. How it works, what trials show, who it suits.
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Tesamorelin and the Aging Brain: One Trial, Many Questions
A 2012 RCT linked the GHRH analogue tesamorelin to better executive function in older adults. Why one trial is not enough, plus safety and legal status.
