Senolytics: Who Should NOT Take Them — A Physician's Safety Guide
A clinical guide to senolytics contraindications: active cancer, cardiac risk, drug interactions, active infection, and the 2026 demyelination finding from PNAS.
Longevity Medicine
Emerging EvidenceSenolytics
Selective elimination of senescent cells to reduce chronic inflammation and aging.
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Senolytics for Osteoporosis: How Clearing Senescent Cells Can Restore Bone Density
The case for senolytic therapy in osteoporosis: how zombie cells disrupt bone remodeling, what the 2024 Phase 2 trial showed, and which patients benefit most.
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FOXO4-DRI and Senolytic Peptides: Mouse Data, Zero Human Trials
FOXO4-DRI cleared senescent cells in aged mice in 2017. No human trial exists. What the peptide does, the evidence gap, safety and legal status.
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Acarbose for Longevity: What the ITP Data Actually Shows
Acarbose extends lifespan in mice by 22% and is the most replicated ITP longevity drug. Here is what the evidence means for human longevity protocols.
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Dasatinib + Quercetin Senolytic Protocol: Dosing, Cycling, and Clinical Evidence
A physician's guide to the D+Q senolytic combination — clinical evidence, dosing schedule, cycling intervals, patient selection, and lab monitoring for longevity practice.
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Pterostilbene vs Resveratrol: Which Stilbene Is Better for Longevity?
Pterostilbene offers 4× greater bioavailability than resveratrol with longer half-life. Compare clinical evidence, dosing, and Dr. Douwes's protocol for stilbene supplementation.
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Inflammaging: How Chronic Low-Grade Inflammation Accelerates Aging (and What to Do About It)
Inflammaging is the chronic low-grade inflammation that rises with age. The science, the markers worth measuring, and which interventions have human evidence.
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mTOR Signaling and Longevity: The Pathway That Controls How Fast You Age
How mTOR drives cellular aging, which compounds inhibit it, and why targeting this pathway is central to modern longevity medicine. Clinical overview by Dr. med. univ. Julian Douwes.
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Rapamycin Dosing for Longevity: Protocols, Timing & Clinical Considerations
A physician's evidence-based guide to rapamycin dosing for longevity: weekly intermittent protocols, dose ranges, lab monitoring, and who should avoid it.
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Apigenin Supplement Benefits: NAD+ Booster, Senolytic & Sleep Aid
Apigenin inhibits CD38 to raise NAD+ levels, clears senescent cells, and deepens sleep. A physician's evidence-based guide to dosing, stacking, and safety.
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Fisetin vs Quercetin: Which Senolytic Flavonoid Is Better?
A physician's comparison of fisetin and quercetin as senolytic agents — mechanisms, evidence, dosing protocols, and which patients benefit from each flavonoid.
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Quercetin as a Senolytic: Protocol, Dosage, and What the Research Shows
Physician guide to quercetin senolytic protocols. Quercetin + dasatinib evidence, quercetin + fisetin alternatives, dosing schedules, and the science of clearing senescent cells.
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Senolytics: Clearing Senescent Cells
How senolytic therapies target zombie cells that drive aging. Dasatinib, quercetin, fisetin -- evidence, protocols, and honest limitations.
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Stem Cell Therapy: What Works, What Doesn't
An honest assessment of stem cell therapy for longevity and regeneration. Separating science from marketing in the stem cell industry.
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Autophagy: How Your Body Recycles Damaged Cells
How to activate autophagy through fasting, exercise, and targeted interventions. The science of cellular self-cleaning, its role in aging, and what actually works.
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Fisetin: The Senolytic Flavonoid You Should Know About
Fisetin senolytic dosing, Mayo Clinic research, mechanism of action, combination with quercetin, and honest evidence grading from a physician who uses senolytics in clinical practice.
