Spermidine vs Urolithin A: Two Autophagy Activators, One Longevity Stack
Spermidine and urolithin A both activate autophagy but through different pathways. A clinical comparison of mechanisms, evidence, dosing, and who benefits from one or both.
Longevity Medicine
Mitophagy
Urolithin A Dosage: Physician's Guide to Timing, Protocol, and the Clinical Evidence.
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Urolithin A Dosage: Physician's Guide to Timing, Protocol, and the Clinical Evidence
Physician-written urolithin A dosage guide: optimal dose from 500mg to 2g, timing, cycling, and stacking protocols backed by clinical evidence.
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Mitophagy: How to Activate Your Cells' Self-Cleaning System for Longevity
Mitophagy removes damaged mitochondria to protect energy, cognition, and lifespan. A physician explains what activates it, what blocks it, and how to optimize it.
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Urolithin A: Activating Mitophagy for Muscle Health and Longevity
Dr. Douwes reviews urolithin A — the gut-derived metabolite that activates mitophagy, preserves muscle function, and extends healthspan in clinical trials.
