Berberine for PCOS: Clinical Evidence, Dosage Protocol, and Integrative Management
How berberine addresses insulin resistance, androgen excess, and anovulation in PCOS — clinical evidence, dosing, and what to combine it with.
Longevity Medicine
Moderate EvidenceHormone Optimization
Testosterone, thyroid, growth hormone, and estrogen optimization for healthspan.
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Ibutamoren (MK-677): A Physician's Guide to the Oral Growth Hormone Secretagogue
Dr. Douwes breaks down MK-677 (ibutamoren): mechanism, dosing, clinical evidence, longevity benefits, and how it compares to injectable GH peptides.
03
Sarcopenia Prevention: A Physician's Guide to Preserving Muscle Mass After 40
Evidence-based strategies for sarcopenia prevention — from resistance training and protein dosing to peptide protocols and hormonal optimization for healthy aging.
04
Pregnenolone: The Neurosteroid That Powers Memory, Mood, and Stress Resilience
Pregnenolone is the master precursor to all steroid hormones. Learn how declining levels affect cognition, stress response, and how to supplement safely under clinical guidance.
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Myo-Inositol & D-Chiro-Inositol: A Physician's Evidence-Based Guide
Dr. Douwes reviews myo-inositol and D-chiro-inositol for PCOS, insulin resistance, egg quality, and anxiety — with dosing, ratios, and clinical evidence.
06
Tongkat Ali: A Physician's Evidence-Based Guide to Dosage, Benefits, and Safety
Dr. Douwes reviews tongkat ali (Eurycoma longifolia) for testosterone, cortisol, and fatigue—covering clinical evidence, optimal dosing, and who actually benefits.
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AOD 9604 Peptide: The hGH Fragment for Fat Loss and Tissue Repair
AOD 9604 is a modified fragment of human growth hormone that targets fat metabolism without raising IGF-1. A physician's guide to dosing, evidence, and safety.
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Sermorelin vs CJC-1295: Which Growth Hormone Peptide Is Right for You?
Sermorelin and CJC-1295 both stimulate growth hormone release, but differ in half-life, pulsatility, and clinical use. A physician's comparison of both peptides.
09
Zinc Supplement Guide: Immune Function, Testosterone & Wound Healing
A physician's evidence-based guide to zinc supplementation — covering dosing, forms, immune support, testosterone, wound healing, and who actually needs it.
10
DHEA Supplementation: Evidence-Based Guide to Anti-Aging and Hormone Health
DHEA declines 80% by age 70. Physician-reviewed guide covering dosing, benefits for cognition, immunity, and bone density, and who should consider it.
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Boron: The Overlooked Mineral for Testosterone, Bone Density, and Inflammation
Dr. Julian Douwes reviews why boron belongs in a serious longevity stack — from free testosterone elevation and bone protection to vitamin D activation and CRP reduction.
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Sermorelin Peptide: A Physician's Guide to Growth Hormone Optimization
Dr. Julian Douwes reviews sermorelin dosing, clinical uses, how it compares to CJC-1295 and ipamorelin, and what patients realistically gain from GH peptide therapy. For a direct comparison of sermorelin against CJC-1295 — including half-life, pulsatility differences, and which patients benefit most from each — see [Sermorelin vs CJC-1295: Which Growth Hormone Peptide Is Right for You?](/blog/peptides-sermorelin-vs-cjc-1295).
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Ipamorelin: A Physician's Guide to Dosage, Benefits, and Clinical Use
Ipamorelin selectively amplifies GH pulses without raising cortisol or prolactin. Physician guide to dosing, stacking with CJC-1295, and candidacy.
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Shilajit: Fulvic Acid, Mitochondrial Energy, and Testosterone Support
A physician's clinical guide to shilajit — how fulvic acid drives mitochondrial energy, supports testosterone, and offers neuroprotective effects. Dosing, forms, and safety.
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Peptide Therapy for Women: What the Clinical Evidence Actually Shows
A physician's evidence-based guide to peptide therapy for women — covering hormonal interactions, key peptides, dosing considerations, and who is a suitable candidate.
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Peptides for Muscle Growth: What the Evidence Actually Supports
Evidence-based review of peptides for muscle growth. GH secretagogues, BPC-157 for recovery, safety risks, and what works based on clinical experience.
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CJC-1295/Ipamorelin vs Tesamorelin: Growth Hormone Secretagogues Compared
A physician's comparison of CJC-1295/Ipamorelin and tesamorelin — mechanisms, evidence, body composition effects, and which GH secretagogue suits which patient.
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CJC-1295/Ipamorelin Dosage: Growth Hormone Protocol
Evidence-based CJC-1295/Ipamorelin dosing guide by Dr. Julian Douwes. Nightly subcutaneous protocols, DAC vs no-DAC, cycling, and growth hormone optimization.
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Hormone Optimization for Women
Estrogen, progesterone, thyroid, and DHEA in aging women. Evidence-based approach to female hormonal health across perimenopause and beyond.
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Hormone Optimization for Men
Testosterone, DHEA, thyroid, and growth hormone in aging men. Evidence-based approach to male hormonal health and longevity.
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The Complete Thyroid Panel: What to Test and Why
TSH alone is not enough. A complete thyroid panel includes free T3, free T4, reverse T3, TPO and TG antibodies. How to interpret results and screen for Hashimoto's.
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Hormone Panels: What to Test and When
Which hormones to test, when to test them, and how to interpret results using optimal ranges rather than just reference ranges.
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Testosterone After 40: What Every Man Should Know
Evidence-based guide to testosterone optimization after 40. Testing, natural decline, the optimization ladder from lifestyle to TRT, risks, benefits, and monitoring — from a physician who treats it daily.
