Supplements

Moderate Evidence

Berberine

AMPK activator with metformin-comparable glucose-lowering effects.

7 articles · 55 min total
01

Berberine Drug Interactions: What Every Patient on Berberine Needs to Know

Berberine inhibits CYP3A4 and P-gp, creating clinically significant interactions with statins, warfarin, cyclosporine, and more. A physician's evidence-based guide.

Berberine Drug Interactions: What Every Patient on Berberine Needs to Know
02

Berberine for PCOS: Clinical Evidence, Dosage Protocol, and Integrative Management

How berberine addresses insulin resistance, androgen excess, and anovulation in PCOS — clinical evidence, dosing, and what to combine it with.

Berberine for PCOS: Clinical Evidence, Dosage Protocol, and Integrative Management
03

Berberine vs Semaglutide: What the Evidence Actually Shows

A physician's evidence-based comparison of berberine and semaglutide for blood sugar control and weight loss — mechanisms, efficacy, safety, and who benefits most.

Berberine vs Semaglutide: What the Evidence Actually Shows
04

Berberine and Blood Sugar: Mechanisms, Evidence, and Clinical Protocols

Dr. Douwes breaks down how berberine lowers blood sugar, what the clinical trials actually show, and the dosing protocol he uses in practice.

Berberine and Blood Sugar: Mechanisms, Evidence, and Clinical Protocols
05

Berberine vs Metformin: AMPK Activation Compared

Head-to-head comparison of berberine and metformin for glucose control, lipids, and longevity. Both activate AMPK — but how do they really compare?

Berberine vs Metformin: AMPK Activation Compared
06

Berberine Dosage for Blood Sugar: Evidence-Based Protocol

Physician guide to berberine dosing for blood sugar, insulin sensitivity, and metabolic health. Optimal doses, timing, GI management, and comparison to metformin.

Berberine Dosage for Blood Sugar: Evidence-Based Protocol
07

Metformin vs. Berberine: AMPK Activators Compared

Head-to-head comparison of metformin and berberine for longevity, AMPK activation, blood sugar, and exercise compatibility. Evidence, dosing, and which to choose.

Metformin vs. Berberine: AMPK Activators Compared
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