At a Glance
| Feature | Detail |
|---|---|
| What it is | Vendor-made blend of three research peptides; also sold as “Tri-Heal Blend” or described as “Coremend” |
| Typical label | TB-500 25 mg + BPC-157 10 mg + KPV 10 mg (45 mg per vial, ratio 2.5:1:1) |
| Rationale | Cell migration and angiogenesis (TB-500), soft-tissue and gut repair signalling (BPC-157), anti-inflammatory signalling (KPV) |
| Route | Subcutaneous injection |
| Typical practice dose | 200–500 mcg of total blend once daily, 4–6 weeks |
| Evidence level | Limited: combination untested; KPV has no human data; BPC-157 and TB-500 have very little |
| Regulatory status | No component approved by FDA or EMA; all three on FDA’s significant-safety-risk compounding list; WADA 2026: prohibited (TB-500 in S2.3, BPC-157 in S0) |
Tri-Heal Max is the least known of the three blends in this library, and I checked that it is a real, defined product before writing about it. An EU research-chemical vendor and an Australian vendor sell it as a 45 mg vial with 25 mg TB-500, 10 mg BPC-157 and 10 mg KPV, and an independent protocol database describes the same 2.5:1:1 formula (peptide-db). A second database describes the same three-peptide blend under the name “Coremend” (PeptideMind).
My verdict: it is a TB-500-heavy healing stack in a single vial, with no data on the combination and dosing advice that does not add up.
The components
| Component | Labelled amount | What the evidence says | Full article |
|---|---|---|---|
| TB-500 | 25 mg | Thymosin beta-4 fragment or analogue; angiogenesis and wound healing in animal models [3] | TB-500 |
| BPC-157 | 10 mg | Mostly rat data; 3 small human studies with 30 participants, very low certainty [2] | BPC-157 |
| KPV | 10 mg | Alpha-MSH tripeptide; reduced colitis in mice via the PepT1 transporter [4]; no human exposure data | KPV |
The only human data involving any two of these is a 16-patient retrospective knee-pain series with intra-articular BPC-157, alone or with thymosin beta-4 [1]. No study has tested this three-peptide combination, in any species or by any route.
Stability and quality concerns
- Measured content can differ a lot from the label. A vendor-supplied certificate for one Tri-Heal Max batch reported about 35 mg TB-500 against 25 mg labelled and about 13.5 mg BPC-157 against 10 mg. Overfill and underfill both change the dose.
- TB-500 identity. The same certificate gives a molecular mass that matches full-length thymosin beta-4, not the 7-amino-acid fragment that the name “TB-500” often refers to. These are different molecules with different evidence.
- No copper. Without GHK-Cu, the copper-catalysed oxidation concern raised for GLOW and KLOW does not apply, but there are no stability data for this mixture after reconstitution either.
Dosing
For informational purposes only — this summarises doses used in research and practice; it is not a prescription or individual medical advice.
| Goal | Dose | Route | Frequency / timing | Cycle length | Basis |
|---|---|---|---|---|---|
| Injury recovery, gut repair (blend protocol) | 200–500 mcg total blend (≈110–280 mcg TB-500, ≈45–110 mcg each of BPC-157 and KPV) | SC | Once daily | 4–6 weeks | Practice protocol (peptide-db, PeptideMind) |
| Separate peptides, for comparison | TB-500 2–5 mg 2×/week; BPC-157 250–500 mcg/day; KPV 500 mcg–1 mg/day | SC (BPC-157 and KPV also oral) | As stated | 4–12 weeks | Practice protocol (see the stacking guide) |
The mismatch is the main point. At 200–500 mcg of blend a day, the BPC-157 dose is about 2 to 10 times lower than when it is used alone, KPV is 5 to 20 times lower, and TB-500 comes to roughly 0.8–2 mg a week, below the usual twice-weekly protocol. Dosing to reach a typical TB-500 amount instead (for example 2.5 mg twice weekly, about 4.5 mg of blend per injection) would deliver about 1 mg each of BPC-157 and KPV per injection. Neither approach rests on data. The blend’s fixed ratio, not biology, decides which component gets the “right” dose.
For injection technique and reconstitution, see the peptide injection guide.
What people report: what works and what doesn’t
Reported to work
- No community threads specifically about Tri-Heal Max turned up in my search. Reports on the separate components and on the BPC-157 plus TB-500 stack describe faster recovery from soft-tissue injuries, but they cannot be transferred to this blend at these doses.
Mixed or unclear
- Whether a low daily blend dose does anything; no user comparisons exist.
Reported not to work, or disappointing
- No reports specific to Tri-Heal Max found. For the related multi-peptide blends, users mostly report injection-site reactions and, less often, nausea, palpitations or poor sleep (see KLOW).
What a proper trial would need to show: a dose-finding study of the blend, then a randomised comparison against BPC-157 plus TB-500 and against placebo on a defined injury outcome.
Safety and legal status
The unknowns of each component add up. TB-500, the largest component here, and BPC-157 both promote new blood vessel growth and cell migration [3], a reason for caution with current or past cancer. KPV’s systemic effects after injection are unstudied. With three agents in one injection, a side effect cannot be attributed.
- United States. None of the components is an approved drug. FDA’s page on bulk substances that may present significant safety risks lists BPC-157, TB-500 and KPV [5].
- EU and Germany. No component is authorised as a medicine; supply for human use is supply of an unauthorised medicinal product.
- Sport. Prohibited at all times: thymosin beta-4 and its derivatives, including TB-500, are named in WADA S2.3, BPC-157 in S0, and KPV falls under S0 as a non-approved substance [6].
Related Articles
- KLOW Peptide Blend: GLOW Plus KPV
- GLOW Peptide Blend: GHK-Cu, BPC-157, TB-500 in One Vial
- BPC-157 vs TB-500: Choosing the Right Healing Peptide
- KPV: The Anti-Inflammatory Tripeptide
- TB-500 Dosage Guide
Frequently asked questions
What is in Tri-Heal Max?
Vendor listings and an independent protocol database describe a 45 mg vial containing 25 mg TB-500, 10 mg BPC-157 and 10 mg KPV, a 2.5:1:1 ratio. It is also sold as 'Tri-Heal Blend' and described under the name 'Coremend'. It contains no GHK-Cu.
How is Tri-Heal Max different from KLOW or GLOW?
GLOW and KLOW are built around 50 mg of the copper peptide GHK-Cu. Tri-Heal Max has no copper peptide and puts most of its weight on TB-500, with BPC-157 and KPV as smaller components. It is marketed for injury recovery and gut inflammation rather than skin.
What dose of Tri-Heal Max do people use?
Two independent protocol sites list 200–500 mcg and 250 mcg of total blend once daily for 4–6 weeks. At those doses each injection contains roughly 110–280 mcg TB-500 and 45–110 mcg each of BPC-157 and KPV, well below what is used when these peptides are taken individually.
References
- Lee E, Padgett B. Intra-Articular Injection of BPC 157 for Multiple Types of Knee Pain. Altern Ther Health Med. 2021. PMID: 34324435. https://pubmed.ncbi.nlm.nih.gov/34324435/
- Poolton JT, Minett J, Kazmi A. Human evidence for BPC-157 in orthopaedic and regenerative medicine: a systematic review of efficacy and safety. Acta Orthop Belg. 2026. PMID: 42885452. https://pubmed.ncbi.nlm.nih.gov/42885452/
- Philp D, Goldstein AL, Kleinman HK. Thymosin beta4 promotes angiogenesis, wound healing, and hair follicle development. Mech Ageing Dev. 2004. PMID: 15037013. https://pubmed.ncbi.nlm.nih.gov/15037013/
- Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, et al. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. 2008. PMID: 18061177. https://pubmed.ncbi.nlm.nih.gov/18061177/
- U.S. Food and Drug Administration. Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks. Content current as of 22 April 2026. https://www.fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-present-significant-safety-risks
- World Anti-Doping Agency. The 2026 Prohibited List (S0; S2.3), as published in Tractatenblad 2026, 25. https://zoek.officielebekendmakingen.nl/trb-2026-25.html
Disclaimer: This article is for information and education only and is not a prescription or individual medical advice. Tri-Heal Max and its components are not approved medicines.
