Gonadorelin: GnRH, Pulse Timing, and the hCG Substitution Problem
Gonadorelin is native GnRH with a 2 to 20 minute half-life. Why pulse frequency decides whether it stimulates or suppresses, plus trials, dosing and law.
Peptide Therapy
Hormone Optimization
2 articles on Hormone Optimization by Dr. med. univ. Julian Douwes: Gonadorelin: GnRH, Pulse Timing, and the hCG Substitution Problem; and more.
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Rapamycin for Women: Dosing, Fertility, Hormonal Interactions, and Clinical Considerations
A physician's guide to rapamycin use in women — how mTOR signaling differs by sex, fertility implications, cycling strategies, and what the evidence actually shows.
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Kisspeptin: The Master Hormone Peptide for LH, Testosterone, and Fertility
Clinical guide to kisspeptin peptide therapy — how it stimulates LH and FSH, restores testosterone, supports fertility, and compares to HCG and enclomiphene.
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Sermorelin Dosage & Protocol Guide: Titration, Timing, and Lab Monitoring
Physician-authored sermorelin dosage guide covering starting doses, titration, bedtime timing, cycle structure, IGF-1 monitoring, and age-specific adjustments.
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Zinc and Testosterone: How Zinc Deficiency Tanks Male Hormones
Zinc directly supports testosterone synthesis, Leydig cell function, and aromatase regulation. Learn optimal dosage, best forms, and lab markers to guide supplementation.
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Sermorelin vs CJC-1295: Which Growth Hormone Peptide Is Right for You?
Sermorelin and CJC-1295 both stimulate growth hormone release, but differ in half-life, pulsatility, and clinical use. A physician's comparison of both peptides.
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Sermorelin Peptide: A Physician's Guide to Growth Hormone Optimization
Dr. med. univ. Julian Douwes reviews sermorelin dosing, clinical uses, how it compares to CJC-1295 and ipamorelin, and what patients realistically gain from GH peptide therapy.
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Hormone Optimization for Women
Estrogen, progesterone, thyroid, and DHEA in aging women. Evidence-based approach to female hormonal health across perimenopause and beyond.
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Hormone Optimization for Men
Testosterone, DHEA, thyroid, and growth hormone in aging men. Evidence-based approach to male hormonal health and longevity.
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Testosterone After 40: What Every Man Should Know
Evidence-based guide to testosterone optimization after 40. Testing, natural decline, the optimization ladder from lifestyle to TRT, risks, benefits, and monitoring — from a physician who treats it daily.
