Rapamycin and Liver Health: What mTOR Inhibition Does to Hepatic Metabolism
How rapamycin targets mTOR in the liver to reverse diet-induced metabolic stress, protect hepatocytes, and what this means for longevity patients with metabolic risk.
Longevity Medicine
Moderate EvidenceRapamycin
mTOR inhibition for lifespan extension — the most replicated result in aging research.
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Rapamycin Side Effects: Longevity Dose vs Transplant Dose — What Patients Need to Know
Understand which rapamycin side effects apply at longevity doses versus transplant doses, what labs to monitor, and clear contraindications for off-label use.
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mTOR Signaling and Longevity: The Pathway That Controls How Fast You Age
How mTOR drives cellular aging, which compounds inhibit it, and why targeting this pathway is central to modern longevity medicine. Clinical overview by Dr. Julian Douwes.
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Rapamycin Dosing for Longevity: Protocols, Timing & Clinical Considerations
A physician's evidence-based guide to rapamycin dosing for longevity: weekly intermittent protocols, dose ranges, lab monitoring, and who should avoid it.
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Rapamycin vs Metformin for Longevity: A Head-to-Head Comparison
A physician's honest comparison of rapamycin and metformin for longevity. mTOR inhibition vs AMPK activation, evidence quality, dosing, and who should use which.
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Rapamycin and mTOR: Longevity's Most Debated Drug
How rapamycin inhibits mTOR to potentially slow aging. Evidence from animal studies, emerging human data, risks, and honest assessment.
