Clinical Protocols
8 articles on Low Dose Naltrexone by Dr. med. univ. Julian Douwes, from the Clinical Protocols library.
How LDN modulates neuroinflammation and opioid-growth-factor signaling in ankylosing spondylitis. Evidence review, dosing protocol, and what patients can expect — from a physician perspective.
How low-dose naltrexone may affect neuroinflammation and opioid signalling in PTSD: an evidence review with the doses studied and how physicians monitor it.
Can LDN slow Parkinson's progression? Dr. Douwes reviews the microglial mechanism, emerging clinical data, dosing protocol, and who is a suitable candidate.
How LDN modulates OGF/OGFr signaling, upregulates NK cell activity, and may reduce tumor growth—with dosing protocols and candidate selection criteria.
Step-by-step LDN titration guide covering starting dose, weekly escalation, timing, common side effects during ramp-up, and when to pause or plateau.
LDN reduces endometriosis pain by modulating neuroinflammation and opioid growth factor signaling. Dr. Douwes reviews dosing protocols and the emerging evidence base.
How LDN modulates opioid growth factor receptors and neuroinflammation to reduce psoriatic arthritis joint pain and skin flares — dosing, evidence, and who benefits most.
A functional medicine approach to psoriasis addressing gut-skin axis, immune modulation, LDN, photobiomodulation, and dietary strategies—backed by clinical evidence.
How LDN modulates mast cell hyperreactivity, what the evidence shows, and the practical titration protocol used in integrative MCAS management.
LDN modulates mu-opioid receptors and TLR4 signalling to reduce itch and inflammation in atopic dermatitis. Learn dosing, monitoring, and who benefits most.
How LDN modulates thyroid autoimmunity, reduces TPO antibodies, and improves symptoms in Hashimoto's. Dosing protocols, mechanisms, and patient selection criteria.
A clinical guide to low-dose naltrexone (LDN) in multiple sclerosis: mechanisms, clinical trial data, dosing protocols, patient selection, and integration with DMTs.
How LDN modulates gut immunity, reduces inflammation, and offers a low-risk adjunct in IBD — dosing, evidence hierarchy, patient selection, and monitoring.
