Clinical Protocols
Low-Dose Naltrexone for Endometriosis: Clinical Evidence and Protocol. Part of the Clinical Protocols library by Dr. med. univ. Julian Douwes
How LDN modulates neuroinflammation and opioid-growth-factor signaling in ankylosing spondylitis. Evidence review, dosing protocol, and what patients can expect — from a physician perspective.
Can LDN slow Parkinson's progression? Dr. Douwes reviews the microglial mechanism, emerging clinical data, dosing protocol, and who is a suitable candidate.
How LDN modulates OGF/OGFr signaling, upregulates NK cell activity, and may reduce tumor growth—with dosing protocols and candidate selection criteria.
Step-by-step LDN titration guide covering starting dose, weekly escalation, timing, common side effects during ramp-up, and when to pause or plateau.
LDN reduces endometriosis pain by modulating neuroinflammation and opioid growth factor signaling. Dr. Douwes reviews dosing protocols and the emerging evidence base.
LDN modulates TLR4 signaling and reduces type-I interferon activity in SLE. Review the clinical evidence, dosing titration, flare monitoring, and drug interactions.
How LDN modulates opioid growth factor receptors and neuroinflammation to reduce psoriatic arthritis joint pain and skin flares — dosing, evidence, and who benefits most.
A functional medicine approach to psoriasis addressing gut-skin axis, immune modulation, LDN, photobiomodulation, and dietary strategies—backed by clinical evidence.
How LDN modulates mast cell hyperreactivity, what the evidence shows, and the practical titration protocol used in integrative MCAS management.
LDN modulates mu-opioid receptors and TLR4 signalling to reduce itch and inflammation in atopic dermatitis. Learn dosing, monitoring, and who benefits most.
How LDN modulates thyroid autoimmunity, reduces TPO antibodies, and improves symptoms in Hashimoto's. Dosing protocols, mechanisms, and patient selection criteria.
A clinical guide to low-dose naltrexone (LDN) in multiple sclerosis: mechanisms, clinical trial data, dosing protocols, patient selection, and integration with DMTs.
How LDN modulates gut immunity, reduces inflammation, and offers a low-risk adjunct in IBD — dosing, evidence hierarchy, patient selection, and monitoring.
LDN reduces fibromyalgia pain by modulating microglial neuroinflammation. Review clinical trial data, optimal dosing protocols, and what to expect in the first 90 days.
LDN reduces neuroinflammation and immune dysregulation driving long COVID fatigue. Clinical evidence, dosing protocol, and how LDN fits a multimodal recovery plan.
Low-dose naltrexone modulates immune function and reduces neuroinflammation. Evidence-based overview of LDN dosing, mechanisms, and clinical applications.
