Peptide Therapy

Metabolic Modulators

Small molecules sold alongside peptides for fat loss and energy metabolism, AICAR and 5-Amino-1MQ: mechanism, human data and doses used.

2 articles · 28 min total

5-Amino-1MQ: The NNMT Inhibitor With No Human Data

5-Amino-1MQ blocks NNMT, raising NAD+ and suppressing fat storage in mice. The rodent evidence is strong and consistent. Human trials: zero. What that means in practice.

Oct 23, 2026 · 14 min read

5-Amino-1MQ: The NNMT Inhibitor With No Human Data

AICAR: The Exercise Mimetic That Needs Grams, Not Milligrams

AICAR activates AMPK and improved endurance in untrained mice. In humans it has been given to thousands of cardiac surgery patients — at gram doses — and failed its definitive trial.

Oct 23, 2026 · 14 min read

AICAR: The Exercise Mimetic That Needs Grams, Not Milligrams

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