Supplements

Strong Evidence

Vitamin D

Beyond bone health — immune modulation, mood, and the optimal range debate.

6 articles · 58 min total
01
Foundational

Vitamin D: The Most Important Supplement Most People Get Wrong

Vitamin D benefits and dosing from a physician. Optimal levels, cofactors K2 and magnesium, immune modulation, LL-37 upregulation, and why most people are deficient.

Vitamin D: The Most Important Supplement Most People Get Wrong
02

Vitamin D as a Neuroimmune Signal: Mental Health Applications Beyond Bone

How vitamin D acts as a lifespan neuroimmune signal in psychiatry — from depression and schizophrenia to autism and cognitive decline. Clinical dosing and evidence.

Vitamin D as a Neuroimmune Signal: Mental Health Applications Beyond Bone
03

Klotho Protein: The Anti-Aging Hormone That Controls How Fast You Age

Klotho protein declines with age and predicts cognitive decline, kidney disease, and cardiovascular risk. Here's what the science says about boosting it.

Klotho Protein: The Anti-Aging Hormone That Controls How Fast You Age
04

Boron: The Overlooked Mineral for Testosterone, Bone Density, and Inflammation

Dr. Julian Douwes reviews why boron belongs in a serious longevity stack — from free testosterone elevation and bone protection to vitamin D activation and CRP reduction.

Boron: The Overlooked Mineral for Testosterone, Bone Density, and Inflammation
05

Anti-Aging Supplements: A Physician's Actual Stack for Longevity

A practicing physician's evidence-based anti-aging supplement stack. NAD+, resveratrol, CoQ10, omega-3, vitamin D — what works, what's overhyped, and what I actually take.

Anti-Aging Supplements: A Physician's Actual Stack for Longevity
06

LL-37 and Vitamin D: The Immune Connection

How vitamin D regulates LL-37 production and why this matters for immunity. The cathelicidin pathway, optimal levels, and clinical implications.

LL-37 and Vitamin D: The Immune Connection
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